ArticleDiagnostics (Basel, Switzerland)2020
Added Value of Subtraction SPECT/CT in Dual-Isotope Parathyroid Scintigraphy.
Article in Diagnostics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 4 citations in OpenAlex.
- Dual-isotope subtraction scintigraphy and SPECT-CT for preoperative localization of parathyroid adenomas.Clinical physiology and functional imaging · 2026Article
- Software-Assisted Subtraction with Ultrasound-Correlated Interpretation Reduces Interpretive Ambiguity in Parathyroid Scintigraphy: A Preliminary Prospective Reporting Study.Diagnostics (Basel, Switzerland) · 2026Article
- Preoperative imaging in primary hyperparathyroidism: AreClinical endocrinology · 2022Article
- Article
- Comparative Study on Effective Dose and Cancer Risk in Dual-tracer Hybrid Imaging - International Commission on Radiological Protection and Personalized Models.Journal of medical physicsArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdding subtraction single-photon emission computed tomography/computed tomography (SPECT/CT) to dual isotope (I-123 and Tc-99m-sestamibi) subtraction parathyroid scintigraphy is not widely implemented. We aimed to assess the added value of dual isotope subtraction SPECT/CT over single isotope SPECT/CT as an adjunct to dual isotope planar pinhole subtraction scintigraphy.
methodsParathyroid scintigraphies from 106 patients with an estimated total of 415 parathyroid glands who (1) were diagnosed with primary hyperparathyroidism, (2) underwent dual isotope subtraction scintigraphy in the Department of Nuclear Medicine, Gentofte Hospital, Denmark throughout 2017 and (3) underwent subsequent parathyroidectomy, were included. The original dual isotope planar pinhole subtraction plus dual isotope subtraction SPECT/CT (dual/dual method) exams were retrospectively re-evaluated using only Tc-99m-sestamibi SPECT/CT (dual/single method). Statistics were calculated per parathyroid. Surgical results confirmed by pathology served as reference standard.
resultsThe dual/dual method had higher sensitivity than the dual/single method (82% (95%CI 74%-88%) vs. 69% (95%CI 60%-77%)) while specificity, positive and negative predictive values (PPV and NPV) were similar (specificity 96% vs. 93%, PPV's 87% vs. 82% and NPV's 89% vs. 93%). Reader confidence was higher when employing the dual/dual method (
conclusionsThe dual/dual method can be considered superior to the dual/single method in the preoperative imaging in primary hyperparathyroidism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.