Evidence map›Paper›PMID 32867034›Full record

ArticleInternational journal of molecular sciences2020

Characteristics of Malignant Pleural Effusion Resident CD8

Rajeev Dhupar, Olugbenga T Okusanya, Seth H Eisenberg, Sara E Monaco, Ayana T Ruffin, Dongyan Liu, James D Luketich, Udai S Kammula, Tullia C Bruno, Michael T Lotze and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Integrating pleural PD-1Frontiers in immunology · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. The Detection of Immunity against WT1 and SMAD4International journal of molecular sciences · 2022
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Rajeev DhuparSurgical Services Division, VA Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA.
Olugbenga T OkusanyaDepartment of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Seth H EisenbergDepartment of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Sara E MonacoDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Ayana T RuffinDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Dongyan LiuDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
James D LuketichDepartment of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Udai S KammulaDepartment of Surgery, Division of Surgical Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Tullia C BrunoDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Michael T LotzeDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Adam C SoloffDepartment of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.ORCID 0000-0002-1467-8168
University of Pittsburgh · US

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jessie Nedrow · 1988 to 2026
$158.0M
Metabolic Reprogramming of Tumor Infiltrating Lymphocytes for Adoptive ImmunotherapyR01CA233521 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KAMMULA, UDAI S · 2019 to 2023
$1.8M
NCI NIH HHS P30 CA047904NCI NIH HHS R01 CA233521
6 · The paper itself

Abstract

While T cell-based cancer immunotherapies have shown great promise, there remains a need to understand how individual metastatic tumor environments impart local T cell dysfunction. At advanced stages, cancers that metastasize to the pleural space can result in a malignant pleural effusion (MPE) that harbors abundant tumor and immune cells, often exceeding 10

Indexed as

AgedAged, 80 and overCD8-Positive T-LymphocytesCell DifferentiationCoculture TechniquesFemaleGene Expression Regulation, NeoplasticHumansInterferon-gammaInterleukin-7 Receptor alpha SubunitLactic AcidLeukocyte Common AntigensL-Lactate DehydrogenaseMaleMiddle AgedMyeloid-Derived Suppressor CellsCCR7 protein, humanIFNG protein, humanIL7R protein, humanInterferon-gammaInterleukin-7 Receptor alpha SubunitLactic AcidLeukocyte Common AntigensL-Lactate DehydrogenaseReceptors, CCR7malignant pleural effusionmetastatic cancerT cell responsetumor immunosuppression

Identifiers

PMID32867034
PMCPMC7503595
OpenAlexW3080580417

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.