ArticleNature2020
Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
127citing papers in PubMed, 1 pooled it
9.1field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
127 citing papers in PubMed, 1 synthesis or guideline pooled it, 208 citations in OpenAlex.
- C1q as a target molecule to treat human disease: What do mouse studies teach us?Frontiers in immunology · 2022Pooled it
- Selective vulnerability and resilience of thalamic neuronal populations in Frontotemporal Dementia.Research square · 2026Article
- Human TDP-43 expression worsens FTD-related phenotypes in progranulin-insufficient mice.Neurobiology of disease · 2026Article
- Article
- Hippocampal neuronal progranulin mediates estrogen‑deficiency‑induced affective vulnerability and lysosomal-autophagic dysfunction.Molecular psychiatry · 2026Article
- Transplantation of human iPSC-derived microglia ameliorates neuropathology and circuit dysfunction in progranulin-deficient mice.Molecular neurodegeneration · 2026Article
- TGF-β signaling promotes astroglial activation and TDP-43 proteinopathy in organoid models of frontotemporal lobar degeneration.The Journal of clinical investigation · 2026Article
- Plasma Proteomic Changes in GRN and C9orf72 Frontotemporal Dementia.European journal of neurology · 2026Article
- Microglial Dysfunction Induced by C9ORF72 Dipeptide Repeat Proteins: Biomarker and Therapeutic Perspectives.International journal of molecular sciences · 2026Review
- Gpnmb defines a phagocytic state of microglia linked to cell death in prion disease mouse model.Nature communications · 2026Article
- Interplay of oxidative stress and neuroinflammation in alzheimer's: insights into age-driven pathogenesis.Inflammopharmacology · 2026Review
- Oligodendrocyte precursor cells-microglia crosstalk via BMP4 drives microglial neuroprotective response and mitigates Alzheimer's disease.Signal transduction and targeted therapy · 2026Article
- Transplantation of Human IPSC-derived Microglia Ameliorates Neuropathology and Circuit Dysfunction in Progranulin-Deficient Mice.Research square · 2026Article
- Induction of neurodegeneration in the hippocampus of senescence-accelerated mouse-prone 8 (SAMP8) mice by blood-brain barrier-crossing serum amyloid P component.Journal of neuroinflammation · 2026Article
- Transplantation of Human IPSC-derived Microglia Ameliorates Neuropathology and Circuit Dysfunction in Progranulin-Deficient Mice.bioRxiv : the preprint server for biology · 2026Article
- Selective neuronal restoration of progranulin does not prevent the frontotemporal dementia like-phenotype of progranulin knockout mice.Journal of neuroinflammation · 2026Article
- AAV9 gene therapy optimization for SMARD1/CMT2S: safety and long-term efficacy comparison of two vectors in a SMARD1 preclinical model.Journal of biomedical science · 2026Article
- Unraveling dynamics of nuclear pore and chromatin via HS-AFM.Anatomical science international · 2026Review
- Region-specific features of early glial activation and Aquaporin-4 dysregulation in conditional mouse models of TDP-43 proteinopathies.Discovery immunology · 2026Article
- The MYO1F interactome reveals ASAP1, CD2AP and SH3KBP1 as novel adaptor proteins in podosomes and phagosomes.Journal of cell science · 2025Article
67 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 4 institutions in 1 country.
Jiasheng Zhang *Department of Pathology, University of California San Francisco, San Francisco, CA, USA.
Dmitry Velmeshev *Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USA.
Kei Hashimoto *Department of Pathology, University of California San Francisco, San Francisco, CA, USA.
Yu-Hsin Huang *Department of Pathology, University of California San Francisco, San Francisco, CA, USA.
Jeffrey W HofmannDepartment of Pathology, University of California San Francisco, San Francisco, CA, USA.
Xiaoyu ShiDepartment of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA.
Jiapei ChenDepartment of Pathology, University of California San Francisco, San Francisco, CA, USA.
Andrew M LeidalDepartment of Pathology, University of California San Francisco, San Francisco, CA, USA.
Julian G DishartDepartment of Pathology, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-0014-6141
Michelle K CahillNeuroscience Graduate Program, University of California San Francisco, San Francisco, CA, USA.
Kevin W KelleyNeuroscience Graduate Program, University of California San Francisco, San Francisco, CA, USA.
Shane A LiddelowNeuroscience Institute, Department of Neuroscience & Physiology, NYU Langone Medical Center, New York, NY, USA.
William W SeeleyNeuroscience Graduate Program, University of California San Francisco, San Francisco, CA, USA.
Bruce L MillerDepartment of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA.
Tobias C WaltherDepartment of Genetics and Complex Diseases, T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1442-1327
Robert V FareseDepartment of Genetics and Complex Diseases, T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
J Paul TaylorDepartment of Cell and Molecular Biology, St Jude Children's Hospital & Howard Hughes Medical Institute, Memphis, TN, USA.
Erik M UllianDepartment of Ophthalmology, University of California San Francisco, San Francisco, CA, USA.
Bo HuangDepartment of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-1704-4141
Jayanta DebnathDepartment of Pathology, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-8745-4069
Torsten WittmannBiomedical Sciences Graduate Program, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-9134-691X
Arnold R KriegsteinEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-5742-2990
Eric J HuangDepartment of Pathology, University of California San Francisco, San Francisco, CA, USA. eric.huang2@ucsf.edu.ORCID http://orcid.org/0000-0002-5381-3801
University of California, San Francisco · USHoward Hughes Medical Institute · USHarvard University · USNYU Langone Health · US
Funding
Research Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Gil Dan Rabinovici · 2019 to 2026
$36.9MDevelopment and Expansion of the Human Cerebral CortexR35NS097305 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRIEGSTEIN, ARNOLD · 2017 to 2024
$8.5MEndolysosomal defects in secretory autophagy and microglial toxicity in FTDR01AG057462 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jayanta Debnath, Eric J Huang · 2017 to 2026
$6.9MA Cellular Resolution Census of the Developing Human BrainU01MH114825 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, ERIC J, KRIEGSTEIN, ARNOLD · 2017 to 2021
$6.7MMapping the Developing Human Neocortex by Massively Parallel Single Cell AnalysisU01MH105989 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRIEGSTEIN, ARNOLD · 2014 to 2016
$5.1MSingle Cell Analyses of Neuroimmune Dysfunctions in the Thalamocortical Circuit in FTLDR01AA027074 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, ERIC J, KRIEGSTEIN, ARNOLD · 2018 to 2022
$3.3M(PQ7) Defining a new mode of RAS signaling in cancer from cytoplasmic protein granulesR01CA231300 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BIVONA, TREVER G, HUANG, BO · 2019 to 2023
$2.3MProgranulin deficiency and microglia senescence in neurodegenerationR01AG068290 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, ERIC J · 2020 to 2024
$2.0MProbing Microtubule Function in Neuronal DevelopmentR01NS107480 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WITTMANN, TORSTEN · 2018 to 2022
$2.0MStructure mapping of molecular complexes by super-resolution microscopyR01GM124334 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, BO · 2018 to 2021
$1.3MElucidating How Primary Cilia Regulate Hedgehog Signaling by Super-Resolution MicroscopyR00GM126136 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI SHI, XIAOYU · 2020 to 2022
$746kSpinning disk confocal / FRAP microscope for quantitative live cell imagingS10RR026758 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WITTMANN, TORSTEN · 2010 to 2010
$500kBLRD VA I01 BX002978NCI NIH HHS R01 CA231300NCRR NIH HHS S10 RR026758NIAAA NIH HHS R01 AA027074NIA NIH HHS P30 AG062422NIA NIH HHS R01 AG057462NIA NIH HHS R01 AG068290NIGMS NIH HHS K99 GM126136NIGMS NIH HHS R00 GM126136NIGMS NIH HHS R01 GM124334NIMH NIH HHS K99 MH121534NIMH NIH HHS U01 MH105989NIMH NIH HHS U01 MH114825NINDS NIH HHS R01 NS107480NINDS NIH HHS R35 NS097305
Abstract
Aberrant aggregation of the RNA-binding protein TDP-43 in neurons is a hallmark of frontotemporal lobar degeneration caused by haploinsufficiency in the gene encoding progranulin
Indexed as
AgingAnimalsCell NucleusComplement ActivationComplement C1qComplement C3bCulture Media, ConditionedDisease Models, AnimalDNA-Binding ProteinsFemaleMaleMiceMicrogliaNeuronsNuclear PoreProgranulinsComplement C1qComplement C3bCulture Media, ConditionedDNA-Binding ProteinsGrn protein, mouseProgranulinsTardbp protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.