ArticleThe Journal of cell biology1988
Organization of microtubules in centrosome-free cytoplasm.
Article in The Journal of cell biology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Exome-wide analysis implicates rare protein-altering variants in human handedness.Nature communications · 2024Article
- Patterns of brain asymmetry associated with polygenic risks for autism and schizophrenia implicate language and executive functions but not brain masculinization.Molecular psychiatry · 2021Article
- Handedness and its genetic influences are associated with structural asymmetries of the cerebral cortex in 31,864 individuals.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The genetic architecture of structural left-right asymmetry of the human brain.Nature human behaviour · 2021Article
- The centrosome and bipolar spindle assembly: does one have anything to do with the other?Cell cycle (Georgetown, Tex.) · 2011Article
- Amphiastral mitotic spindle assembly in vertebrate cells lacking centrosomes.Current biology : CB · 2011Article
- Perspectives and open problems in the early phases of left-right patterning.Seminars in cell & developmental biology · 2009Review
- Is left-right asymmetry a form of planar cell polarity?Development (Cambridge, England) · 2009Article
- Cytoskeletal dynamics during mammalian gametegenesis and fertilization: Implications for human reproduction.Reproductive medicine and biology · 2005Review
- Microtubule organization during rabbit fertilization by intracytoplasmic sperm injection with and without sperm centrosome.Reproductive medicine and biology · 2005Article
- Encounters between dynamic cortical microtubules promote ordering of the cortical array through angle-dependent modifications of microtubule behavior.The Plant cell · 2004Article
- A kinesin mutant with an atypical bipolar spindle undergoes normal mitosis.Molecular biology of the cell · 2003Article
- Identification of MINUS, a small polypeptide that functions as a microtubule nucleation suppressor.The EMBO journal · 1999Article
- Self-centering in cytoplasmic fragments of melanophores.Molecular biology of the cell · 1998Article
- Molecular structure of the sarcomeric M band: mapping of titin and myosin binding domains in myomesin and the identification of a potential regulatory phosphorylation site in myomesin.The EMBO journal · 1997Article
- The role of microtubules and microtubule-organising centres during the migration of mitochondria.Journal of anatomy · 1996Article
- Overexpression of cytoplasmic dynein's globular head causes a collapse of the interphase microtubule network in Dictyostelium.Molecular biology of the cell · 1996Article
- Microtubule dynamics in fish melanophores.The Journal of cell biology · 1994Article
- Mechanism of centrosome positioning during the wound response in BSC-1 cells.The Journal of cell biology · 1992Article
- Regulation of microtubule dynamics and nucleation during polarization in MDCK II cells.The Journal of cell biology · 1990Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many different cell types possess microtubule patterns which appear to be polarized and oriented, in part, by cytoplasmic factors not directly associated with a centrosome. Recently, we demonstrated that cytoplasmic extensions ("arms") of teleost melanophores will reorganize their microtubule population outward from their centers after surgical isolation (McNiven, M. A., M. Wang, and K. R. Porter. 1984. Cell. 37:753-765). In the study reported here, we examine microtubule dynamics within the centrosome-free fragments and find that, after severing, microtubule reorganization is initiated at the proximal (cut) end of an arm and migrates distally with the aggregated pigment mass until it becomes permanently positioned at the middle of the arm. Computer-aided image analysis demonstrates that this middle position is located at the arm centroid, implicating the action of a cytoplasmic gel in this process. Morphological studies of arms devoid of pigment reveal that microtubules do not emanate from a single site or structure within the centroid area, but from a more generalized region. Taken together, these findings suggest that factors distributed throughout cytoplasm participate in microtubule assembly and organization.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.