Evidence map›Paper›PMID 32866574›Full record

SynthesisAnnals of vascular surgery2021

Arterial Thrombosis in Coronavirus Disease 2019 Patients: A Rapid Systematic Review.

Isaac Cheruiyot, Vincent Kipkorir, Brian Ngure, Musa Misiani, Jeremiah Munguti, Julius Ogeng'o

Open access · bronzeAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Annals of vascular surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed
10.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 439 citations in OpenAlex.

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  19. The spectrum of COVID-19-associated chorioretinal vasculopathy.American journal of ophthalmology case reports · 2023
    Article
  20. Review

34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Isaac CheruiyotDepartment of Human Anatomy, School of Medicine, University of Nairobi, Nairobi, Kenya. Electronic address: isaacbmn@outlook.com.
Vincent KipkorirDepartment of Human Anatomy, School of Medicine, University of Nairobi, Nairobi, Kenya.
Brian NgureDepartment of Human Anatomy, School of Medicine, University of Nairobi, Nairobi, Kenya.
Musa MisianiDepartment of Human Anatomy, School of Medicine, University of Nairobi, Nairobi, Kenya.
Jeremiah MungutiDepartment of Human Anatomy, School of Medicine, University of Nairobi, Nairobi, Kenya.
Julius Ogeng'oDepartment of Human Anatomy, School of Medicine, University of Nairobi, Nairobi, Kenya.
University of Nairobi · KE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEmerging evidence suggests that severe form of coronavirus disease 2019 (COVID-19) is mediated, in part, by a hypercoagulable state characterized by micro- and macro-vascular thrombotic angiopathy. Although venous thrombotic events in COVID-19 patients have been well described, data on arterial thrombosis (AT) in these patients is still limited. We, therefore, conducted a rapid systematic review of current scientific literature to identify and consolidate evidence of AT in COVID-19 patients.

methodsA systematic search of literature was conducted between November 1, 2019, and June 9, 2020, on PubMed and China National Knowledge Infrastructure to identify potentially eligible studies.

resultsA total of 27 studies (5 cohort, 5 case series, and 17 case reports) describing arterial thrombotic events in 90 COVID-19 patients were included. The pooled incidence of AT in severe/critically ill intensive care unit-admitted COVID-19 patients across the 5 cohort studies was 4.4% (95% confidence interval 2.8-6.4). Most of the patients were male, elderly, and had comorbidities. AT was symptomatic in >95% of these patients and involved multiple arteries in approximately 18% of patients. The anatomical distribution of arterial thrombotic events was wide, occurring in limb arteries (39%), cerebral arteries (24%), great vessels (aorta, common iliac, common carotid, and brachiocephalic trunk; 19%), coronary arteries (9%), and superior mesenteric artery (8%). The mortality rate in these patients is approximately 20%.

conclusionsAT occurs in approximately 4% of critically ill COVID-19 patients. It often presents symptomatically and can affect multiple arteries. Further investigation of the underlying mechanism of AT in COVID-19 would be needed to clarify possible therapeutic targets.

Indexed as

Blood CoagulationAdultAgedAged, 80 and overArterial Occlusive DiseasesCOVID-19Host-Pathogen InteractionsHumansIncidenceMaleMiddle AgedPrognosisRisk FactorsSARS-CoV-2Thrombosis

Identifiers

PMID32866574
PMCPMC7453204
OpenAlexW3080236684

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.