SynthesisThe lancet. Psychiatry2020
Effectiveness of digital psychological interventions for mental health problems in low-income and middle-income countries: a systematic review and meta-analysis.
Synthesis in The lancet. Psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 159 papers, 24 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
159 citing papers in PubMed, 24 syntheses or guidelines pooled it.
- Therapeutic Interaction Features of AI Chatbots in Depression Interventions: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2026Pooled it
- Use of Technology to Support Health Care Providers Delivering Care in Low- and Lower-Middle-Income Countries: Systematic Umbrella Review.Journal of medical Internet research · 2025Pooled it
- The Efficacy of Nurse-Delivered Psychosocial and Psychotherapeutic Interventions for Individuals With Mental Health Issues: A Meta-Analysis of Randomised Controlled Trials.Scandinavian journal of caring sciences · 2025Pooled it
- Stress management interventions for university students in low-and middle-income countries: a systematic review and meta-analysis.Frontiers in digital health · 2025Pooled it
- Positive association between Internet use and mental health among adults aged ≥50 years in 23 countries.Nature human behaviour · 2025Pooled it
- Barriers to and facilitators of user engagement with web-based mental health interventions in young people: a systematic review.European child & adolescent psychiatry · 2025Pooled it
- The effectiveness of digital psychosocial interventions on psychological distress, depression, anxiety, and health-related quality of life in patients with gynaecological cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Pooled it
- Transdiagnostic Psychological Interventions for Symptoms of Common Mental Disorders Delivered by Non-Specialist Providers in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis.Depression and anxiety · 2024Pooled it
- A mixed methods systematic review of mental health self-care strategies for Arabic-speaking refugees and migrants.BMC public health · 2023Pooled it
- The Use of Mobile Assessments for Monitoring Mental Health in Youth: Umbrella Review.Journal of medical Internet research · 2023Pooled it
- Effectiveness of digital psychological interventions in reducing perinatal depression: a systematic review of meta-analyses.Archives of women's mental health · 2023Pooled it
- Time-Dependent Changes in Depressive Symptoms Among Control Participants in Digital-Based Psychological Intervention Studies: Meta-analysis of Randomized Controlled Trials.Journal of medical Internet research · 2023Pooled it
- Providing Human Support for the Use of Digital Mental Health Interventions: Systematic Meta-review.Journal of medical Internet research · 2023Pooled it
- The Relationship Between Physical Activity and Mobile Phone Addiction Among Adolescents and Young Adults: Systematic Review and Meta-analysis of Observational Studies.JMIR public health and surveillance · 2022Pooled it
- Digital training for building resilience: Systematic review, meta-analysis, and meta-regression.Stress and health : journal of the International Society for the Investigation of Stress · 2022Pooled it
- Automated Digital Interventions and Smoking Cessation: Systematic Review and Meta-analysis Relating Efficiency to a Psychological Theory of Intervention Perspective.Journal of medical Internet research · 2022Pooled it
- Impact of connected health interventions on psychological wellbeing and quality of life in patients with cancer: A systematic review and meta-analysis.Psycho-oncology · 2022Pooled it
- Community-based mental health and well-being interventions for older adults in low- and middle-income countries: a systematic review and meta-analysis.BMC geriatrics · 2022Pooled it
- Comparability of Patients in Trials of eHealth and Face-to-Face Psychotherapeutic Interventions for Depression: Meta-synthesis.Journal of medical Internet research · 2022Pooled it
- Meta-Analysis of Psychological Interventions for Reducing Stress, Anxiety, and Depression among University Students during the COVID-19 Pandemic.International journal of environmental research and public health · 2022Pooled it
99 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe effectiveness of digital psychological interventions in low-income and middle-income countries (LMICs) remains unclear. We aimed to systematically investigate the available evidence for digital psychological interventions in reducing mental health problems in LMICs.
methodsIn this systematic review and meta-analysis, we searched PubMed, PsycINFO, Embase, and Cochrane databases for articles published in English from database inception to March 9, 2020. We included randomised controlled trials investigating digital psychological interventions in individuals with mental health problems in LMICs. We extracted data on demographics, inclusion and exclusion criteria, details of the intervention, including the setting, digital delivery method, control group conditions, number of sessions, therapeutic orientation (eg, cognitive therapy or behaviour therapy), presence or absence of guidance, and length of follow-up, and statistical information to calculate effect sizes. If a study reported insufficient data to calculate effect sizes, the corresponding authors were contacted to provide data that could be aggregated. We did random-effects meta-analyses, and calculated the standardised mean difference in scores of digital psychological interventions versus control conditions (Hedges'g). Quality of evidence was assessed by use of the Grading of Recommendations Assessment, Development, and Evaluation approach. The primary outcome was post-intervention mental health problems, as measured by self-reporting instruments or clinical interviews. This study is registered with PROSPERO, CRD42019137755.
findingsWe identified 22 eligible studies that were included in the meta-analysis. The included studies involved a total of 4104 participants (2351 who received a digital psychological intervention and 1753 who were in the control group), and mainly focused on young adults (mean age of the study population was 20-35 years) with depression or substance misuse. The results showed that digital psychological interventions are moderately effective when compared with control interventions (Hedges'g 0·60 [95% CI 0·45-0·75]; Hedges'g with treatment as usual subgroup for comparison 0·54 [0·35-0·73]). Heterogeneity between studies was substantial (I
interpretationDigital psychological interventions, which have been mostly studied in individuals with depression and substance misuse, are superior to control conditions, including usual care, and are moderately effective in LMICs. However, the considerable heterogeneity observed in our analysis highlights the need for more studies to be done, with standardised implementation of digital psychological intervention programmes to improve their reproducibility and efficiency. Digital psychological interventions should be considered for regions where usual care for mental health problems is minimal or absent.
fundingNone. TRANSLATIONS: For the Persian, Chinese, Hindi, Portuguese, Bahasa, Turkish, Romanian, Spanish and Thai translations of the abstract see Supplementary Materials section.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.