Evidence map›Paper›PMID 32866336›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2020

A Unified Framework for Understanding Nucleophilicity and Protophilicity in the S

Pascal Vermeeren, Thomas Hansen, Paul Jansen, Marcel Swart, Trevor A Hamlin, F Matthias Bickelhaupt

Abstract read
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
  2. Article
  3. Understanding the SChemistry (Weinheim an der Bergstrasse, Germany) · 2025
    Review
  4. Non-Aqueous Binary and TernaryJournal of the American Chemical Society · 2025
    Article
  5. Selenium Nucleophilicity and Electrophilicity in the Intra- and Intermolecular SChemistry (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  6. Article
  7. Article
  8. Benchmark Ab Initio Mapping of the FThe journal of physical chemistry. A · 2024
    Article
  9. Solvent-induced dual nucleophiles and the α-effect in the SPhysical chemistry chemical physics : PCCP · 2024
    Article
  10. Article
  11. E2/SPrecision chemistry · 2023
    Article
  12. Effects of Methyl Substitution and Leaving Group on E2/SMolecules (Basel, Switzerland) · 2023
    Article
  13. Rational design of iron catalysts for C-X bond activation.Journal of computational chemistry · 2023
    Article
  14. Rational Tuning of the Reactivity of Three-Membered Heterocycle Ring Openings via SChemistry (Weinheim an der Bergstrasse, Germany) · 2022
    Article
  15. C-X Bond Activation by Palladium: Steric Shielding versus Steric Attraction.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022
    Article
  16. Article
  17. SThe Journal of organic chemistry · 2022
    Article
  18. C(spChemistry (Weinheim an der Bergstrasse, Germany) · 2022
    Article
  19. How Solvation Influences the SThe Journal of organic chemistry · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pascal VermeerenDepartment of Theoretical Chemistry, Amsterdam Institute of, Molecular and Life Sciences (AIMMS), Amsterdam Center for Multiscale, Modeling (ACMM), Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081, HV, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-2100-6837
Thomas HansenDepartment of Theoretical Chemistry, Amsterdam Institute of, Molecular and Life Sciences (AIMMS), Amsterdam Center for Multiscale, Modeling (ACMM), Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081, HV, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-6291-1569
Paul JansenDepartment of Theoretical Chemistry, Amsterdam Institute of, Molecular and Life Sciences (AIMMS), Amsterdam Center for Multiscale, Modeling (ACMM), Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081, HV, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-2520-0258
Marcel SwartICREA, Pg. Lluís Companys 23, 08010, Barcelona, Spain.ORCID http://orcid.org/0000-0002-8174-8488
Trevor A HamlinDepartment of Theoretical Chemistry, Amsterdam Institute of, Molecular and Life Sciences (AIMMS), Amsterdam Center for Multiscale, Modeling (ACMM), Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081, HV, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-5128-1004
F Matthias BickelhauptDepartment of Theoretical Chemistry, Amsterdam Institute of, Molecular and Life Sciences (AIMMS), Amsterdam Center for Multiscale, Modeling (ACMM), Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081, HV, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0003-4655-7747

Funding

Nederlandse Organisatie voor Wetenschappelijk Onderzoek
6 · The paper itself

Abstract

The concepts of nucleophilicity and protophilicity are fundamental and ubiquitous in chemistry. A case in point is bimolecular nucleophilic substitution (S

Indexed as

activation strain modelbond theorydensity functional calculationsnucleophilicityprotophilicity

Identifiers

PMID32866336
PMCPMC7756690

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.