ArticlePLoS pathogens2020
Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates.
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Article in PLoS pathogens, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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69citing papers in PubMed
7.7field-weighted citation impact, top 2% of its field
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Who cites it
69 citing papers in PubMed, 90 citations in OpenAlex.
- Vaccination with mRNA-encoded membrane-anchored HIV envelope trimers elicited tier 2 neutralizing antibodies in a phase 1 clinical trial.Science translational medicine · 2025Trial
- HIV-1 BG505 SOSIP immunization induced B cell expansion targeting the 465-glycan hole, with neutralizing antibodies exhibiting distinct binding modes and mechanisms of virus inhibition.PLoS pathogens · 2026Article
- Differential contributions of human oligosaccharyltransferase complexes OST-A and OST-B to HIV-1 envelope glycoprotein glycosylation.Journal of virology · 2026Article
- Vaccine elicitation of HIV-1 neutralizing antibodies against both V2 apex and fusion peptide in rhesus macaques.Cell reports · 2026Article
- Population-level genomic analysis of immunoglobulin loci variation in rhesus macaques reveals extensive germline diversity.Immunity · 2026Article
- Germline-Targeting Strategies to Induce bNAbs against HIV-1.Current HIV research · 2026Review
- Structural and immunological characterization of the H3 influenza hemagglutinin during antigenic drift.Nature communications · 2025Article
- Novel HIV-1 fusion peptide immunogens using glycan-engineered alphavirus-like particles.NPJ vaccines · 2025Article
- Vaccine Elicitation of HIV-1 Neutralizing Antibodies Against Both V2 Apex and Fusion Peptide in Rhesus Macaques.bioRxiv : the preprint server for biology · 2025Article
- Immunofocusing on the conserved fusion peptide of HIV envelope glycoprotein in rhesus macaques.NPJ vaccines · 2025Article
- Accelerated cGMP production of near-native HIV-1 Env trimers following electroporation transfection and immunogenicity analysis.NPJ vaccines · 2025Article
- Vaccination with an mRNA-encoded membrane-bound HIV envelope trimer induces neutralizing antibodies in animal models.Science translational medicine · 2025Article
- Fusion of Complement Fragment C3d Enhances Germinal Center Responses to HIV-1 Envelope Glycoproteins.bioRxiv : the preprint server for biology · 2025Article
- Immunofocusing on the conserved fusion peptide of HIV envelope glycoprotein in rhesus macaques.bioRxiv : the preprint server for biology · 2025Article
- Convergence and divergence of B cell responses in two HIV-1 Env immunizations in Rhesus macaques.Communications medicine · 2025Article
- Defining bottlenecks and opportunities for Lassa virus neutralization by structural profiling of vaccine-induced polyclonal antibody responses.Cell reports · 2024Article
- Immunization of cows with HIV envelope trimers generates broadly neutralizing antibodies to the V2-apex from the ultralong CDRH3 repertoire.PLoS pathogens · 2024Article
- Germline-targeting HIV vaccination induces neutralizing antibodies to the CD4 binding site.Science immunology · 2024Article
- Priming antibody responses to the fusion peptide in rhesus macaques.NPJ vaccines · 2024Article
- Ultrapotent Broadly Neutralizing Human-llama Bispecific Antibodies against HIV-1.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
9 more citing papers are in PubMed but not listed here.
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Authors and funding
31 authors at 7 institutions in 2 countries.
Christopher A CottrellDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.ORCID 0000-0002-3364-3083
Jelle van SchootenDepartment of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0002-5202-355X
Charles A BowmanDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.ORCID 0000-0001-6142-0947
Meng YuanDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.
David OyenDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.
Mia ShinDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.ORCID 0000-0002-1607-5301
Robert MorpurgoDepartment of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0001-7611-0634
Patricia van der WoudeDepartment of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Mariëlle van BreemenDepartment of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Jonathan L TorresDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.ORCID 0000-0003-0137-8497
Raj PatelDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.
Justin GrossDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.ORCID 0000-0001-5132-9533
Leigh M SewallDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.ORCID 0000-0002-2020-2991
Jeffrey CoppsDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.ORCID 0000-0003-4793-7258
Gabriel OzorowskiDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.ORCID 0000-0002-9695-8138
Bartek NogalDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.ORCID 0000-0001-8977-7470
Devin SokIAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.ORCID 0000-0002-9354-1740
Eva G RakaszWisconsin National Primate Research Center, University of Wisconsin, Madison, Wisconsin, United States of America.
Celia LabrancheDepartment of Surgery, Duke University Medical Center, Durham, North Carolina, United States of America.ORCID 0000-0002-6653-6655
Vladimir VigdorovichCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, United States of America.ORCID 0000-0003-4195-4858
Scott ChristleyDepartment of Population and Data Sciences, UT Southwestern Medical Center, Dallas, Texas, United States of America.
Diane G CarnathanConsortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, California, United States of America.
D Noah SatherCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, United States of America.ORCID 0000-0002-9128-172X
David MontefioriDepartment of Surgery, Duke University Medical Center, Durham, North Carolina, United States of America.ORCID 0000-0003-0856-6319
Guido SilvestriConsortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, California, United States of America.ORCID 0000-0001-6602-2470
Dennis R BurtonIAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America.ORCID 0000-0001-6711-9864
John P MooreDepartment of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, United States of America.
Ian A WilsonDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.
Rogier W SandersDepartment of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0002-2324-8573
Andrew B WardDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America.ORCID 0000-0001-7153-3769
Marit J van GilsDepartment of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0003-3422-8161
Scripps Research Institute · USAmsterdam University Medical Centers · NLCornell University · USDuke Medical Center · USInfectious Disease Research Institute · USSouthwestern Medical Center · USUniversity of Wisconsin–Madison · US
Funding
Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0MWNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7MSupport Component D/Vaccine Discovery, Concept to ClinicUM1AI100663 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI MCELRATH, MARGARET JULIANA · 2012 to 2018
$131.5MStructural studies of native-like SOSIP trimersP01AI110657 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI MOORE, JOHN P · 2015 to 2024
$35.4MX-ray Absorption Spectroscopy (XAS) pp.711-759P41GM103393 · NIGMS · STANFORD UNIVERSITY · PI HODGSON, KEITH O · 2012 to 2019
$30.6MNeutralization of Primate Immunodeficiency VirusesR01AI036082 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI JOHN P MOORE · 1994 to 2026
$4.3MCOMPUTING AND DATA STORAGE CLUSTER FOR ELECTRON MICROSCOPYS10OD021634 · OD · SCRIPPS RESEARCH INSTITUTE, THE · PI LANDER, GABRIEL C · 2016 to 2016
$531kBroadening autologous Tier 2 anti-HIV neutralizing antibodiesF31AI131873 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI COTTRELL, CHRISTOPHER ANDREW · 2017 to 2020
$95kNIAID NIH HHS F31 AI131873NIAID NIH HHS P01 AI110657NIAID NIH HHS R01 AI036082NIAID NIH HHS UM1 AI100663NIGMS NIH HHS P41 GM103393NIH HHS P51 OD011106NIH HHS P51 OD011132NIH HHS S10 OD021634
Abstract
The induction of broad and potent immunity by vaccines is the key focus of research efforts aimed at protecting against HIV-1 infection. Soluble native-like HIV-1 envelope glycoproteins have shown promise as vaccine candidates as they can induce potent autologous neutralizing responses in rabbits and non-human primates. In this study, monoclonal antibodies were isolated and characterized from rhesus macaques immunized with the BG505 SOSIP.664 trimer to better understand vaccine-induced antibody responses. Our studies reveal a diverse landscape of antibodies recognizing immunodominant strain-specific epitopes and non-neutralizing neo-epitopes. Additionally, we isolated a subset of mAbs against an epitope cluster at the gp120-gp41 interface that recognize the highly conserved fusion peptide and the glycan at position 88 and have characteristics akin to several human-derived broadly neutralizing antibodies.
Indexed as
Epitope MappingAIDS VaccinesAnimalsAntibodies, Monoclonal, Murine-DerivedEpitopesHIV-1HIV AntibodiesHIV Envelope Protein gp120HIV Envelope Protein gp41Macaca mulattaProtein MultimerizationAIDS VaccinesAntibodies, Monoclonal, Murine-DerivedEpitopesgp120 protein, Human immunodeficiency virus 1gp41 protein, Human immunodeficiency virus 1HIV AntibodiesHIV Envelope Protein gp120HIV Envelope Protein gp41
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.