ArticlePloS one2020
Cardiorespiratory fitness diminishes the effects of age on white matter hyperintensity volume.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Associations of cardiorespiratory fitness and exercise with brain white matter in healthy adults: A systematic review and meta-analysis.Brain imaging and behavior · 2022Pooled it
- Associations of cardiorespiratory fitness with brain white matter microstructural integrity and white matter hyperintensity volume across the adult lifespan.GeroScience · 2026Article
- Cardiorespiratory fitness and cardiometabolic health are associated with distinct cognitive domains in cognitively healthy older adults.Scientific reports · 2025Article
- Effects of Aging, Estimated Fitness, and Cerebrovascular Status on White Matter Microstructural Health.Human brain mapping · 2025Article
- Endothelial-Ercc1 DNA repair deficiency provokes blood-brain barrier dysfunction.Cell death & disease · 2025Article
- Healthy dietary intake diminishes the effect of cerebral small vessel disease on cognitive performance in older adults.Frontiers in neurology · 2025Article
- Evidence of association between higher cardiorespiratory fitness and higher cerebral myelination in aging.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Exploring the neuroprotective role of physical activity in cerebral small vessel disease.Brain research · 2024Review
- Cardiorespiratory Fitness and Muscular Strength Do Not Predict Social Cognitive Capacity in Older Age.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023Article
- Getting Fit to Counteract Cognitive Aging: Evidence and Future Directions.Physiology (Bethesda, Md.) · 2022Review
- Article
- Housing quality and behavior affect brain health and anxiety in healthy Japanese adults.Scientific reports · 2021Article
- Midlife Cardiovascular Fitness Is Reflected in the Brain's White Matter.Frontiers in aging neuroscience · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
White matter hyperintensities (WMHs) are among the most commonly observed marker of cerebrovascular disease. Age is a key risk factor for WMH development. Cardiorespiratory fitness (CRF) is associated with increased vessel compliance, but it remains unknown if high CRF affects WMH volume. This study explored the effects of CRF on WMH volume in community-dwelling older adults. We further tested the possibility of an interaction between CRF and age on WMH volume. Participants were 76 adults between the ages of 59 and 77 (mean age = 65.36 years, SD = 3.92) who underwent a maximal graded exercise test and structural brain imaging. Results indicated that age was a predictor of WMH volume (beta = .32, p = .015). However, an age-by-CRF interaction was observed such that higher CRF was associated with lower WMH volume in older participants (beta = -.25, p = .040). Our findings suggest that higher levels of aerobic fitness may protect cerebrovascular health in older adults.
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Registered trials
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