Evidence map›Paper›PMID 32865986›Full record

ArticleAnalytical chemistry2020

Simple Targeted Assays for Metabolic Pathways and Signaling: A Powerful Tool for Targeted Proteomics.

Dominik Kopczynski, Andreas Hentschel, Cristina Coman, Nils Helge Schebb, Thorsten Hornemann, Douglas G Mashek, Nicole M Hartung, Olga Shevchuk, Hans-Frieder Schött, Kristina Lorenz and 8 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 11 institutions in 8 countries.

Dominik KopczynskiLeibniz-Institut für Analytische Wissenschaften - ISAS - e.V., Otto-Hahn-Strasse 6b, 44227 Dortmund, Germany.ORCID 0000-0001-5885-4568
Andreas HentschelLeibniz-Institut für Analytische Wissenschaften - ISAS - e.V., Otto-Hahn-Strasse 6b, 44227 Dortmund, Germany.
Cristina ComanLeibniz-Institut für Analytische Wissenschaften - ISAS - e.V., Otto-Hahn-Strasse 6b, 44227 Dortmund, Germany.ORCID 0000-0002-3771-2410
Nils Helge SchebbInstitute for Food Toxicology, University of Veterinary Medicine Hannover, Bischofsholer Damm 15, 30173 Hannover, Germany.
Thorsten HornemannInstitute of Clinical Chemistry, University Hospital Zürich, Wagistrasse 14 Schlieren, 8952 Zürich, Switzerland.
Douglas G MashekDivision of Diabetes, Endocrinology and Metabolism, Department of Medicine, University of Minnesota, 401 East River Parkway, Minneapolis, Minnesota 55455, United States.
Nicole M HartungChair of Food Chemistry, Faculty of Mathematics and Natural Sciences, University of Wuppertal, Gauss-Strasse 20, 42119 Wuppertal, Germany.
Olga ShevchukLeibniz-Institut für Analytische Wissenschaften - ISAS - e.V., Otto-Hahn-Strasse 6b, 44227 Dortmund, Germany.
Hans-Frieder SchöttLeibniz-Institut für Analytische Wissenschaften - ISAS - e.V., Otto-Hahn-Strasse 6b, 44227 Dortmund, Germany.
Kristina LorenzLeibniz-Institut für Analytische Wissenschaften - ISAS - e.V., Otto-Hahn-Strasse 6b, 44227 Dortmund, Germany.
Federico TortaSingapore Lipidomics Incubator (SLING), Department of Biochemistry, YLL School of Medicine, National University of Singapore, 28 Medical Drive, #03-03, Singapore 117456, Singapore.
Bo BurlaSingapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, 28 Medical Drive, #03-03, Singapore 117456, Singapore.ORCID 0000-0002-5918-3249
René P ZahediSegal Cancer Proteomics Centre, Lady Davis Institute, Jewish General Hospital, McGill University, 3755 Cote Sainte Catherine Road, Montreal, Quebec H3T 1E2, Canada.
Albert SickmannLeibniz-Institut für Analytische Wissenschaften - ISAS - e.V., Otto-Hahn-Strasse 6b, 44227 Dortmund, Germany.
Michael R KreutzLeibniz Group "Dendritic Organelles and Synaptic Function", University Medical Center Hamburg-Eppendorf, Center for Molecular Neurobiology, ZMNH, Martinistrasse 52, 20251 Hamburg, Germany.
Christer S EjsingDepartment of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, Odense M DK-5230, Denmark.
Jan MedenbachInstitute of Biochemistry I, University of Regensburg, Universitätsstraße 31, 93053 Regensburg, Germany.
Robert AhrendsLeibniz-Institut für Analytische Wissenschaften - ISAS - e.V., Otto-Hahn-Strasse 6b, 44227 Dortmund, Germany.ORCID 0000-0003-0232-3375
Leibniz Institute for Analytical Sciences - ISAS · DENational University of Singapore · SGUniversity of Vienna · ATUniversity of Wuppertal · DEJewish General Hospital · CAUniversität Hamburg · DEUniversity Hospital of Zurich · CHUniversity of Aberdeen · GBUniversity of Minnesota · USUniversity of Regensburg · DEUniversity of Southern Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We introduce STAMPS, a pathway-centric web service for the development of targeted proteomics assays. STAMPS guides the user by providing several intuitive interfaces for a rapid and simplified method design. Applying our curated framework to signaling and metabolic pathways, we reduced the average assay development time by a factor of ∼150 and revealed that the insulin signaling is actively controlled by protein abundance changes in insulin-sensitive and -resistance states. Although at the current state STAMPS primarily contains mouse data, it was designed for easy extension with additional organisms.

Indexed as

Metabolic Networks and PathwaysSignal TransductionAnimalsChromatography, High Pressure LiquidDatabases, ProteinInsulinMicePeptidesProteomicsTandem Mass SpectrometryInsulinPeptides

Identifiers

PMID32865986
PMCPMC7586293
OpenAlexW3082104531

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.