Evidence map›Paper›PMID 32865974›Full record

ArticleACS chemical neuroscience2020

Ligand with Two Modes of Interaction with the Dopamine D

Richard Ågren, Hugo Zeberg, Tomasz Maciej Stępniewski, R Benjamin Free, Sean W Reilly, Robert R Luedtke, Peter Århem, Francisco Ciruela, David R Sibley, Robert H Mach and 3 more

Open access · hybridAbstract read
In one paragraph

Article in ACS chemical neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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  5. Review
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  8. Article
  9. ONC206 as a low-potency dopamine DNeuro-oncology advances
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 4 countries.

Richard ÅgrenDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm 171 77, Sweden.
Hugo ZebergDepartment of Neuroscience, Karolinska Institutet, Stockholm 171 77, Sweden.
Tomasz Maciej StępniewskiResearch Programme on Biomedical Informatics (GRIB), Department of Experimental and Health Sciences of Pompeu Fabra University (UPF)-Hospital del Mar Medical Research Institute (IMIM), 08003 Barcelona, Spain.
R Benjamin FreeMolecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke, Intramural Research Program, National Institutes of Health, Bethesda, Maryland 20892-3723, United States.ORCID 0000-0002-2428-0487
Sean W ReillyDepartment of Radiology, Division of Nuclear Medicine and Clinical Molecular Imaging, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, United States.ORCID 0000-0002-1656-1895
Robert R LuedtkeDepartment of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, Texas 76107, United States.
Peter ÅrhemDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm 171 77, Sweden.
Francisco CiruelaPharmacology Unit, Department of Pathology and Experimental Therapeutics, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, L'Hospitalet de Llobregat 08907, Spain.
David R SibleyMolecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke, Intramural Research Program, National Institutes of Health, Bethesda, Maryland 20892-3723, United States.ORCID 0000-0002-0624-962X
Robert H MachDepartment of Radiology, Division of Nuclear Medicine and Clinical Molecular Imaging, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, United States.ORCID 0000-0002-7645-2869
Jana SelentResearch Programme on Biomedical Informatics (GRIB), Department of Experimental and Health Sciences of Pompeu Fabra University (UPF)-Hospital del Mar Medical Research Institute (IMIM), 08003 Barcelona, Spain.ORCID 0000-0002-1844-4449
Johanna NilssonDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm 171 77, Sweden.
Kristoffer SahlholmDepartment of Neuroscience, Karolinska Institutet, Stockholm 171 77, Sweden.ORCID 0000-0001-6536-1972
Karolinska Institutet · SENational Institutes of Health · USUniversitat Pompeu Fabra · ESUniversity of Pennsylvania · USInstitut d'Investigació Biomédica de Bellvitge · ESUniversity of North Texas · US

Funding

Molecular And Pharmacological Studies Of Dopamine ReceptorsZIANS002263 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI SIBLEY, DAVID · 2009 to 2025
$37.4M
Molecular &Pharmacological Studies Of Dopamine ReceptorZ01NS002263 · NINDS · NEUROLOGICAL DISORDERS AND STROKE · PI SIBLEY, DAVID R. · 1985 to 2008
$3.1M
Intramural NIH HHS Z01 NS002263Intramural NIH HHS ZIA NS002263
6 · The paper itself

Abstract

A solid understanding of the mechanisms governing ligand binding is crucial for rational design of therapeutics targeting the dopamine D

Indexed as

DopamineReceptors, Dopamine D2Dopamine D2 Receptor AntagonistsGTP-Binding ProteinsLigandsDopamineDopamine D2 Receptor AntagonistsGTP-Binding ProteinsLigandsReceptors, Dopamine D2antipsychoticsarrestincompetitive bindingdrug kineticsHEK cellsmolecular dynamics simulationPET scanXenopus oocytes

Identifiers

PMID32865974
PMCPMC7553383
OpenAlexW3081528659

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.