ReviewCurrent topics in behavioral neurosciences2020
The Role of Opiates in Social Pain and Suicidal Behavior.
Review in Current topics in behavioral neurosciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Biological research on mental pain, social pain and other pains not primarily felt in the body: methodological systematic review.The British journal of psychiatry : the journal of mental science · 2025Pooled it
- Targeting Psychological Pain After a Suicide Attempt: Scoping Review and Intervention Protocol.Journal of clinical medicine · 2026Review
- Association Between Opioid Analgesics and Suicide Attempts: A Nationwide French Case-Crossover Study.CNS drugs · 2025Observational
- Progesterone receptor distribution in the human hypothalamus and its association with suicide.Acta neuropathologica communications · 2024Article
- Chronic pain conditions and risk of suicidal behavior: a 10-year longitudinal co-twin control study.BMC medicine · 2023Article
- Multiple suicide attempts associated with addiction to tramadol.Annals of general psychiatry · 2022Article
- The role of social isolation in opioid addiction.Social cognitive and affective neuroscience · 2021Article
- Traumatic grief research and care in the aftermath of the COVID-19 pandemic.European journal of psychotraumatologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With more than 800,000 deaths by suicide each year and 20 to 30 times more suicide attempts worldwide, suicide is a major public health problem. Current treatments of SB are mainly based on pharmacological treatments that are not specific of SB (e.g. antidepressants), and new therapeutic targets are urgently needed. Recent data strengthen the ancient conception pain (social, psychic, physical) that is at the core of the suicidal process and should be incorporated in the clinical assessment of suicide risk. Then, the mechanisms involved in the regulation of pain may open new avenues regarding therapeutic perspectives. Opiates appear to be a promising candidate in treatment of SB. Indeed, since the last two decades, growing evidences suggest an implication of the opioid system in the pathophysiology of SB, this conduct to the elaboration of randomized controlled trials (RCTs) using opiates in patients with SB. Results suggesting an anti-suicidal effect of buprenorphine and the potential opioidergic-related anti-suicidal effect of ketamine both contribute to the growing interest in opiates use in SB. In this review, we will summarize a large part of the evidence that leads researchers and clinicians to be interested in the use of opiates for SB treatment and discuss on new opioid pharmacological options for suicidal patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.