Evidence map›Paper›PMID 32865497›Full record

SynthesisJournal of medical Internet research2020

Effects of Internet-Based Cognitive Behavioral Therapy in Routine Care for Adults in Treatment for Depression and Anxiety: Systematic Review and Meta-Analysis.

Anne Etzelmueller, Christiaan Vis, Eirini Karyotaki, Harald Baumeister, Nickolai Titov, Matthias Berking, Pim Cuijpers, Heleen Riper, David Daniel Ebert

Erratum issued 3 registry-linked trialsAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of medical Internet research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 3 registered trials, which are not on this map. Cited by 180 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
180citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06797245 narecruitingnot on this mapstarted 2025, after this paper: background citation

The APPROVE Trial: A Randomized Controlled Trial Evaluating the Efficacy and Safety of a Prescription Digital Therapeutic for Treatment of Overactive Bladder in Women

TypeinterventionalSponsorMedstar Health Research InstituteRan2025 to 2028Enrolled596ConditionsOveractive Bladder (OAB), Urinary Urgency, Urinary Urge Incontinence (UUI), NocturiaArmsRiSolve App, AUGS Patient Handouts
NCT07113548 narecruitingnot on this mapstarted 2025, after this paper: background citation

PERSONAE: a Personalized Adaptation of Stepped Care Internet-based Cognitive Behavioral Therapy for Depression - A Randomized Controlled Trial

TypeinterventionalSponsorRegion of Southern DenmarkRan2025 to 2027Enrolled175ConditionsDepression - Major Depressive DisorderArmsPersonalized iCBT for depression, Standard iCBT
NCT07206446 nacompletednot on this mapstarted 2025, after this paper: background citation

A Prospective Evaluation of a Prescription Digital Therapeutic for Treatment of Overactive Bladder in Women: The RiSolve Trial

TypeinterventionalSponsorUniversity of GalwayRan2025 to 2026Enrolled46ConditionsOveractive Bladder (OAB), Over Active BladderArmsRiSolve
3 · Its place in the literature

Who cites it

180 citing papers in PubMed, 11 syntheses or guidelines pooled it.

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120 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Anne EtzelmuellerDepartment of Clinical Psychology and Psychotherapy, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.ORCID 0000-0001-8833-6067
Christiaan VisDepartment of Clinical, Neuro-, & Developmental Psychology, Faculty of Behavioural and Movement Sciences, VU Amsterdam, Amsterdam, Netherlands.ORCID 0000-0001-8783-8487
Eirini KaryotakiDepartment of Clinical, Neuro-, & Developmental Psychology, Faculty of Behavioural and Movement Sciences, VU Amsterdam, Amsterdam, Netherlands.ORCID 0000-0002-0071-2599
Harald BaumeisterDepartment of Clinical Psychology and Psychotherapy, Institute of Psychology and Education, Ulm University, Ulm, Germany.ORCID 0000-0002-2040-661X
Nickolai TitoveCentre Clinic Department of Psychology, Macquarie University, Sydney, Australia.ORCID 0000-0002-7268-729X
Matthias BerkingDepartment of Clinical Psychology and Psychotherapy, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.ORCID 0000-0001-5903-4748
Pim CuijpersDepartment of Clinical, Neuro-, & Developmental Psychology, Faculty of Behavioural and Movement Sciences, VU Amsterdam, Amsterdam, Netherlands.ORCID 0000-0001-5497-2743
Heleen RiperDepartment of Clinical, Neuro-, & Developmental Psychology, Faculty of Behavioural and Movement Sciences, VU Amsterdam, Amsterdam, Netherlands.ORCID 0000-0002-8144-8901
David Daniel EbertDepartment of Clinical Psychology and Psychotherapy, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.ORCID 0000-0001-6820-0146

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough there is evidence for the efficacy of internet-based cognitive behavioral therapy (iCBT), the generalizability of results to routine care is limited.

objectiveThis study systematically reviews effectiveness studies of guided iCBT interventions for the treatment of depression or anxiety.

methodsThe acceptability (uptake, participants' characteristics, adherence, and satisfaction), effectiveness, and negative effects (deterioration) of nonrandomized pre-post designs conducted under routine care conditions were synthesized using systematic review and meta-analytic approaches.

resultsA total of 19 studies including 30 groups were included in the analysis. Despite high heterogeneity, individual effect sizes of investigated studies indicate clinically relevant changes, with effect sizes ranging from Hedges' g=0.42-1.88, with a pooled effect of 1.78 for depression and 0.94 for anxiety studies. Uptake, participants' characteristics, adherence, and satisfaction indicate a moderate to high acceptability of the interventions. The average deterioration across studies was 2.9%.

conclusionsThis study provides evidence supporting the acceptability and effectiveness of guided iCBT for the treatment of depression and anxiety in routine care. Given the high heterogeneity between interventions and contexts, health care providers should select interventions that have been proven in randomized controlled clinical trials. The successful application of iCBT may be an effective way of increasing health care in multiple contexts.

Indexed as

AdultAnxiety DisordersCognitive Behavioral TherapyDepressionFemaleHumansInternet-Based InterventionMaleYoung Adultacceptabilityanxietydepressioneffectivenessinternet-based interventionsroutine care

Identifiers

PMID32865497
PMCPMC7490682

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.