ArticleActa physiologica (Oxford, England)2021
Hydrophobic interactions between the HA helix and S4-S5 linker modulate apparent Ca
Article in Acta physiologica (Oxford, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
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- Channelopathy-causing mutations in the SCell calcium · 2022Article
- Subtype-selective positive modulation of KBritish journal of pharmacology · 2022Article
- Structure-Activity Relationship Study of Subtype-Selective Positive Modulators of KJournal of medicinal chemistry · 2022Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
aimSmall-conductance Ca
methodsSite-directed mutagenesis, electrophysiological recordings and molecular dynamic (MD) simulations were utilized.
resultsMutations that decrease hydrophobicity at the HA-S4-S5 interface lead to Ca
conclusionThe electrophysiological data and MD simulations collectively suggest a crucial role of the interactions between the HA helix and S4-S5 linker in the apparent Ca
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Registered trials
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