Evidence map›Paper›PMID 32865061›Full record

ArticleThe Journal of international medical research2020

(Z)-7,4'-dimethoxy-6-hydroxy-aurone-4-O-

Qiang Song, Xuegang Xie, Zhi Hu, Jianying Xue, Songlin Zhang, Xinming Xie

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of international medical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Qiang SongDepartment of Structural Heart Disease, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China.
Xuegang XieDepartment of Structural Heart Disease, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China.
Zhi HuDepartment of Structural Heart Disease, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China.
Jianying XueDepartment of Structural Heart Disease, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China.
Songlin ZhangDepartment of Structural Heart Disease, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China.
Xinming XieDepartment of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China.ORCID https://orcid.org/0000-0002-8130-8618
First Affiliated Hospital of Xi'an Jiaotong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveExcessive inflammatory responses in the endocardium are related to progression of infectious endocarditis. This study aimed to investigate whether (Z)-7,4'-dimethoxy-6-hydroxy-aurone-4-O-β-glucopyranoside (DHAG), a compound isolated from the endophytic fungus

methodsLTA-induced cell damage occurred in H9c2 cells and the protective effects of DHAG at different concentrations (1-10  µM) were assessed. Indicators of oxidative stress and inflammatory responses in H9c2 cells were measured.

resultsDHAG (1-10  µM) significantly attenuated LTA-induced damage in H9c2 cells, as evidenced by increased cell viability and mitochondrial membrane potential, decreased cytochrome c release and DNA fragmentation, inhibition of caspase-3 and -9 activity, and altered expression of apoptosis-related proteins. DHAG also decreased oxidative stress by increasing protein expression of nuclear factor (erythroid-derived 2)-like 2 (Nrf2). Furthermore, DHAG inhibited inflammatory responses by decreasing protein expression of nuclear factor kappa B (NF-κB) and mitogen-activated protein kinases (MAPKs).

conclusionDHAG exerted protective effects against LTA-induced cell damage, at least partially by decreasing oxidative stress and inhibiting inflammatory responses. Our results provide a scientific rational for developing DHAG as a therapy against infectious endocarditis.

Indexed as

LipopolysaccharidesTeichoic AcidsAnimalsApoptosisBenzofuransNF-kappa BOxidative StressPenicilliumRatsauroneBenzofuransLipopolysaccharideslipoteichoic acidNF-kappa BTeichoic AcidsapoptosisInfectious endocarditisinflammatory responselipoteichoic acidoxidative stress(Z)-7,4'-dimethoxy-6-hydroxy-aurone-4-O-β-glucopyranoside

Identifiers

PMID32865061
PMCPMC7469747
OpenAlexW3081824317

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.