Evidence map›Paper›PMID 32865014›Full record

ArticleAmerican journal of physiology. Renal physiology2020

(Pro)renin receptor decoy peptide PRO20 protects against adriamycin-induced nephropathy by targeting the intrarenal renin-angiotensin system.

Renfei Luo, Kevin Yang, Fei Wang, Chuanming Xu, Tianxin Yang

Abstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Role of (pro) renin receptor in adriamycin-induced cardiomyopathy.International journal of cardiology. Heart & vasculature · 2026
    Article
  2. Renal tubular (pro)renin receptor deletion exacerbates kidney injury inAmerican journal of physiology. Renal physiology · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Therapeutic potential ofFrontiers in pharmacology · 2023
    Article
  8. Review
  9. Article
  10. Review
  11. Role of (pro)renin receptor in cyclosporin A-induced nephropathy.American journal of physiology. Renal physiology · 2022
    Article
  12. Article
  13. Soluble (Pro)Renin Receptor as a Negative Regulator of NCC (NaHypertension (Dallas, Tex. : 1979) · 2021
    Article
  14. Article
  15. (Pro)renin receptor in the kidney: function and significance.American journal of physiology. Regulatory, integrative and comparative physiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Renfei LuoDepartment of Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City, Utah.
Kevin YangDepartment of Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City, Utah.
Fei WangDepartment of Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City, Utah.
Chuanming XuDepartment of Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City, Utah.
Tianxin YangDepartment of Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City, Utah.

Funding

Interaction of PGE2 and intrarenal RAS in AngII-induced hypertensionR01DK104072 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI YANG, TIANXIN · 2015 to 2025
$3.7M
Role of (pro)renin receptor in aldosterone signaling in the kidneyR01HL139689 · NHLBI · UNIVERSITY OF UTAH · PI YANG, TIANXIN · 2018 to 2021
$2.3M
Interaction of (pro)renin receptor and PPARy in regulation of plasma volumeR01HL135851 · NHLBI · UNIVERSITY OF UTAH · PI YANG, TIANXIN · 2017 to 2021
$2.3M
BLRD VA IK6 BX005223NHLBI NIH HHS R01 HL135851NHLBI NIH HHS R01 HL139689NIDDK NIH HHS R01 DK104072
6 · The paper itself

Abstract

Adriamycin (ADR) administration in susceptible rodents such as the BALB/c mouse strain produces injury to the glomerulus mimicking human chronic kidney disease due to primary focal segmental glomerulosclerosis. The goal of the present study was to use this model to investigate antiproteinuric actions of the (pro)renin receptor decoy inhibitor PRO20. BALB/c mice were pretreated for 1 day with PRO20 at 500 μg·kg

Indexed as

Angiotensin IIAnimalsAntihypertensive AgentsDoxorubicinGlomerulosclerosis, Focal SegmentalHydrogen PeroxideKidney DiseasesMice, Inbred BALB CPeptide FragmentsPodocytesProtective AgentsReninRenin-Angiotensin SystemAngiotensin IIAntihypertensive AgentsDoxorubicinHydrogen PeroxidePeptide FragmentsPRO20 peptideProtective AgentsReninadriamycinangiotensing IINADPH oxidase 4(pro)renin receptortransient receptor potential cation channels

Identifiers

PMID32865014
PMCPMC7701266

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.