ArticleBrain and behavior2020
Effects of mood episodes and comorbid anxiety on neuropsychological impairment in patients with bipolar spectrum disorder.
Article in Brain and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 10 citations in OpenAlex.
- Cognitive functions in euthymic bipolar I and II patients: a cross sectional study.Frontiers in psychiatry · 2025Article
- Discrepancy of social cognition between bipolar disorders and major depressive disorders.Brain and behavior · 2024Article
- Impairment in Emotional Intelligence May Be Mood-Dependent in Bipolar I and Bipolar II Disorders.Frontiers in psychiatry · 2021Article
- Effects of mood episodes and comorbid anxiety on neuropsychological impairment in patients with bipolar spectrum disorder.Brain and behavior · 2020Article
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
Abstract
objectivesCases of patients with bipolar disorder (BD) having neuropsychological impairment have been reported, although inconsistently. The possibility of comorbidity with anxiety disorder (AD) has been suggested. The association between mood episodes and AD comorbidity on neuropsychological performance is unclear and thus was investigated in the current study.
methodsAll participants were informed about and agreed to participate in this study. Patients with BD were recruited from outpatient and inpatient settings, and healthy controls (HCs) were recruited as a comparison group. Six hundred and twenty-eight participants (175 HCs and 453 BD-56 BDI and 397 BDII) were studied based on their current mood episode, namely, depressive (BD
resultsCompared to HCs, all BD groups had significantly more impaired neuropsychological profiles, but the BDeu group was found to have less impairment in memory and executive function than the episodic BD groups. The percentage of AD comorbidity in BDd, BDm, BDmix, and BDeu was 33.9%, 40.3%, 33.0%, and 35.6%, respectively (χ
conclusionMemory impairment and executive dysfunction may be state-like cognitive phenotypes and are affected by AD comorbidity during mixed and depressive episodes in BD, while sustained attention deficiencies are more like trait markers, regardless of mood episodes, and persist beyond the course of the illness. The AD comorbidity effect on attentional deficit is greater when suffering from a manic episode.
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