Evidence map›Paper›PMID 32864804›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2020

Zwitterionic 3D-Printed Non-Immunogenic Stealth Microrobots.

Pol Cabanach, Abdon Pena-Francesch, Devin Sheehan, Ugur Bozuyuk, Oncay Yasa, Salvador Borros, Metin Sitti

Open access · hybridAbstract read
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
16.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 164 citations in OpenAlex.

  1. Article
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  8. Transport of Adoptive Cell Transfers With Magnetic Helical Microrobots.Small (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  9. Review
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  11. Magnetically Controllable and Degradable Milliscale Swimmers as Intraocular Drug Implants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 5 countries.

Pol CabanachPhysical Intelligence Department, Max Planck Institute for Intelligent Systems, Stuttgart, 70569, Germany.
Abdon Pena-FranceschPhysical Intelligence Department, Max Planck Institute for Intelligent Systems, Stuttgart, 70569, Germany.ORCID https://orcid.org/0000-0002-7779-1651
Devin SheehanPhysical Intelligence Department, Max Planck Institute for Intelligent Systems, Stuttgart, 70569, Germany.
Ugur BozuyukPhysical Intelligence Department, Max Planck Institute for Intelligent Systems, Stuttgart, 70569, Germany.
Oncay YasaPhysical Intelligence Department, Max Planck Institute for Intelligent Systems, Stuttgart, 70569, Germany.
Salvador BorrosGrup d'Enginyeria de Materials, Institut Químic de Sarrià, Universitat Ramon Llull, Barcelona, 08017, Spain.
Metin SittiPhysical Intelligence Department, Max Planck Institute for Intelligent Systems, Stuttgart, 70569, Germany.ORCID https://orcid.org/0000-0001-8249-3854
Max Planck Institute for Intelligent Systems · DEInstitut Químic de Sarrià · ESKoç University · TRUniversity of Michigan · US

Funding

Alexander von Humboldt FoundationEuropean Research Council 834531European Social Fund 2019 FI_B2 00165Federal Ministry for Education and Research of GermanyGeneralitat de CatalunyaMinisterio de Ciencia, Innovación y Universidades 2017 1559Ministerio de Ciencia, Innovación y Universidades RTI2018-094734-B-C22
6 · The paper itself

Abstract

Microrobots offer transformative solutions for non-invasive medical interventions due to their small size and untethered operation inside the human body. However, they must face the immune system as a natural protection mechanism against foreign threats. Here, non-immunogenic stealth zwitterionic microrobots that avoid recognition from immune cells are introduced. Fully zwitterionic photoresists are developed for two-photon polymerization 3D microprinting of hydrogel microrobots with ample functionalization: tunable mechanical properties, anti-biofouling and non-immunogenic properties, functionalization for magnetic actuation, encapsulation of biomolecules, and surface functionalization for drug delivery. Stealth microrobots avoid detection by macrophage cells of the innate immune system after exhaustive inspection (>90 hours), which has not been achieved in any microrobotic platform to date. These versatile zwitterionic materials eliminate a major roadblock in the development of biocompatible microrobots, and will serve as a toolbox of non-immunogenic materials for medical microrobot and other device technologies for bioengineering and biomedical applications.

Indexed as

Immune EvasionPrinting, Three-DimensionalRoboticsHydrogelsMaterials TestingMechanical PhenomenaMicrotechnologySurface PropertiesHydrogelsmacrophagesnon-immunogenic propertiesstealth microrobotstwo-photon polymerizationzwitterionic materials

Identifiers

PMID32864804
PMCPMC7610461
OpenAlexW3081912382

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.