Evidence map›Paper›PMID 32864636›Full record

ArticleCell reports. Medicine2020

Discovery and Verification of Extracellular miRNA Biomarkers for Non-invasive Prediction of Pre-eclampsia in Asymptomatic Women.

Srimeenakshi Srinivasan, Ryan Treacy, Tiffany Herrero, Richelle Olsen, Trevor R Leonardo, Xuan Zhang, Peter DeHoff, Cuong To, Lara G Poling, Aileen Fernando and 25 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Review
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  5. Article
  6. Review
  7. Article
  8. Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025
    Article
  9. Review
  10. Extracellular Vesicles as Biomarkers of Pregnancy Complications.International journal of molecular sciences · 2024
    Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors.

Srimeenakshi SrinivasanDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego, La Jolla, CA 92037, USA.
Ryan TreacySera Prognostics, 2749 East Parleys Way, Salt Lake City, UT 84109, USA.
Tiffany HerreroDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego, La Jolla, CA 92037, USA.
Richelle OlsenDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego, La Jolla, CA 92037, USA.
Trevor R LeonardoDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego, La Jolla, CA 92037, USA.
Xuan ZhangNeurology and Radiology Services and Program in Neuroscience, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02115, USA.
Peter DeHoffDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego, La Jolla, CA 92037, USA.
Cuong ToDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego, La Jolla, CA 92037, USA.
Lara G PolingDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego, La Jolla, CA 92037, USA.
Aileen FernandoDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego, La Jolla, CA 92037, USA.
Sandra Leon-GarciaDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego, La Jolla, CA 92037, USA.
Katharine KnepperDepartment of Pathology, University of California, San Diego, La Jolla, CA 92037, USA.
Vy TranDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego, La Jolla, CA 92037, USA.
Morgan MeadsDepartment of Pathology, University of California, San Diego, La Jolla, CA 92037, USA.
Jennifer TasarzDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego, La Jolla, CA 92037, USA.
Aishwarya VuppalaDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego, La Jolla, CA 92037, USA.
Soojin ParkDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego, La Jolla, CA 92037, USA.
Clara D LaurentDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego, La Jolla, CA 92037, USA.
Tony BuiDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego, La Jolla, CA 92037, USA.
Pike See CheahNeurology and Radiology Services and Program in Neuroscience, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02115, USA.
Rachael Tabitha OvercashDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego, La Jolla, CA 92037, USA.
Gladys A RamosDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego, La Jolla, CA 92037, USA.
Hilary RoederDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego, La Jolla, CA 92037, USA.
Ionita GhiranDepartment of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Mana ParastDepartment of Pathology, University of California, San Diego, La Jolla, CA 92037, USA.
PAPR Study Consortium
Xandra O BreakefieldNeurology and Radiology Services and Program in Neuroscience, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02115, USA.
Amir J LuethSera Prognostics, 2749 East Parleys Way, Salt Lake City, UT 84109, USA.
Sharon R RustSera Prognostics, 2749 East Parleys Way, Salt Lake City, UT 84109, USA.
Max T DuffordSera Prognostics, 2749 East Parleys Way, Salt Lake City, UT 84109, USA.
Angela C FoxSera Prognostics, 2749 East Parleys Way, Salt Lake City, UT 84109, USA.
Durlin E HickokSera Prognostics, 2749 East Parleys Way, Salt Lake City, UT 84109, USA.
Julja BurchardSera Prognostics, 2749 East Parleys Way, Salt Lake City, UT 84109, USA.
J Jay BonifaceSera Prognostics, 2749 East Parleys Way, Salt Lake City, UT 84109, USA.
Louise C LaurentDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego, La Jolla, CA 92037, USA.

Funding

TRAINING IN REPRODUCTIVE SCIENCEST32HD007203 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PAMELA L MELLON · 1988 to 2026
$4.8M
Reference Profiles of ExRNAs in Normal Human PregnancyU01HL126494 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LAURENT, LOUISE CHANG · 2014 to 2018
$3.4M
ExRNAs for Early Identification of Pregnancies at Risk for Placental DysfunctionUH3TR000906 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LAURENT, LOUISE CHANG · 2015 to 2017
$1.1M
NCATS NIH HHS UH3 TR000906NHLBI NIH HHS U01 HL126494NICHD NIH HHS T32 HD007203
6 · The paper itself

Abstract

Development of effective prevention and treatment strategies for pre-eclampsia is limited by the lack of accurate methods for identification of at-risk pregnancies. We performed small RNA sequencing (RNA-seq) of maternal serum extracellular RNAs (exRNAs) to discover and verify microRNAs (miRNAs) differentially expressed in patients who later developed pre-eclampsia. Sera collected from 73 pre-eclampsia cases and 139 controls between 17 and 28 weeks gestational age (GA), divided into separate discovery and verification cohorts, are analyzed by small RNA-seq. Discovery and verification of univariate and bivariate miRNA biomarkers reveal that bivariate biomarkers verify at a markedly higher rate than univariate biomarkers. The majority of verified biomarkers contain miR-155-5p, which has been reported to mediate the pre-eclampsia-associated repression of endothelial nitric oxide synthase (eNOS) by tumor necrosis factor alpha (TNF-α). Deconvolution analysis reveals that several verified miRNA biomarkers come from the placenta and are likely carried by placenta-specific extracellular vesicles.

Indexed as

AdultAsymptomatic DiseasesBiomarkersCase-Control StudiesExtracellular VesiclesFemaleGestational AgeHumansMaternal Serum Screening TestsMicroRNAsPre-EclampsiaPregnancyPrognosisYoung AdultBiomarkersMicroRNAs

Identifiers

PMID32864636
PMCPMC7455024

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.