ReviewMedicine in drug discovery2020
Development and Clinical Application of Phosphorus-Containing Drugs.
Review in Medicine in drug discovery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed.
- QSAR modeling and in vitro studies of the selective action of triphenylphosphonium salts as anticancer agents against the rhabdomyosarcoma cell line.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026Article
- Article
- Iron-Photocatalyzed C(spAngewandte Chemie (International ed. in English) · 2026Article
- Phosphonamidates Integrating Sterically Hindered Phenols with Membrane-Active Cations: A Redox-Activated Approach to Antimicrobial Agents.International journal of molecular sciences · 2026Article
- Article
- Crystal structures of the homologues diethyl and dimethyl (10Acta crystallographica. Section E, Crystallographic communications · 2026Article
- A light-weight Graph Neural Network for the prediction ofJournal of cheminformatics · 2026Article
- Phosphoramidate Derivatives of Betulin, New Molecules with Promising Biological Activity: Synthesis and Characterization.Molecules (Basel, Switzerland) · 2026Article
- The use of minerals, plants and burnt materials in ancient medicine: Approaches to working recipes in John the Physician'sProceedings of the Geologists' Association. Geologists' Association · 2026Article
- Article
- Synthesis of diaryl phosphates using phytic acid as a phosphorus source.Beilstein journal of organic chemistry · 2026Article
- Phosphorylation of peptides by a kinase domain in cyanobactin pathways.Nature communications · 2025Article
- Stereoselective Pudovik reaction of aldehydes, aldimines, and nitroalkenes with CAMDOL-derived H-phosphonate.Communications chemistry · 2025Article
- Pyrrole-Imine Macrocycle: Self-Organizing Cross-Reactive Anion Receptor and Sensor.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Acidifying agents impact erlotinib and gefitinib pharmacokinetic parameters and elevate liver enzymes in Wistar rats.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2025Article
- Improved Synthesis of a Sub-Nanomolar Vinyl Phosphonate Inhibitor of Dehydroquinate Synthase.Molecules (Basel, Switzerland) · 2025Article
- Selective Phosphorylation of Phenols and Benzenediols by the Kinase PsiK and Variants Thereof.Angewandte Chemie (International ed. in English) · 2025Article
- Design, synthesis and bioactivity evaluation of phosphinanes as potential anticancer agents.Scientific reports · 2025Article
- Photocatalytic Hydrophosphination Using Calcium Precatalysts.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Phosphorus-Derived Isatin Hydrazones: Synthesis, Structure, Thromboelastography, Antiplatelet, and Anticoagulation Activity Evaluation.International journal of molecular sciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phosphorus-containing drugs belong to an important class of therapeutic agents and are widely applied in daily clinical practices. Structurally, the phosphorus-containing drugs can be classified into phosphotriesters, phosphonates, phosphinates, phosphine oxides, phosphoric amides, bisphosphonates, phosphoric anhydrides, and others; functionally, they are often designed as prodrugs with improved selectivity and bioavailability, reduced side effects and toxicity, or biomolecule analogues with endogenous materials and antagonistic endoenzyme supplements. This review summarized the phosphorus-containing drugs currently on the market as well as a few promising molecules at clinical studies, with particular emphasis on their structural features, biological mechanism, and indications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.