Evidence map›Paper›PMID 32864564›Full record

ArticleNanoscale advances2019

A multifunctional biodegradable brush polymer-drug conjugate for paclitaxel/gemcitabine co-delivery and tumor imaging.

Haotian Sun, Lingyue Yan, Michael Yu Zarng Chang, Kevin A Carter, Runsheng Zhang, Leigh Slyker, Jonathan F Lovell, Yun Wu, Chong Cheng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanoscale advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Haotian SunDepartment of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, New York 14260, USA.
Lingyue YanDepartment of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, New York 14260, USA.
Michael Yu Zarng ChangDepartment of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, New York 14260, USA.
Kevin A CarterDepartment of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, New York 14260, USA.
Runsheng ZhangDepartment of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, New York 14260, USA.
Leigh SlykerDepartment of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, New York 14260, USA.
Jonathan F LovellDepartment of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, New York 14260, USA.
Yun WuDepartment of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, New York 14260, USA.
Chong ChengDepartment of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, New York 14260, USA.
State University of New York · US

Funding

Synthetic Biodegradable Zwitterionic PolymersR21EB024095 · NIBIB · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI CHENG, CHONG, WU, YUN · 2017 to 2018
$433k
NIBIB NIH HHS R21 EB024095
6 · The paper itself

Abstract

A multifunctional biodegradable brush polymer-drug conjugate (BPDC) is developed for the co-delivery of hydrophobic paclitaxel (PTX) and hydrophilic gemcitabine (GEM) chemotherapeutics, as well as a tumor imaging agent. A novel ternary copolymer of conventional, acetylenyl-functionalized and allyl-functionalized lactides is prepared to serve as the backbone precursor of BPDC. Acetylenyl groups of the copolymer are then reacted with poly(ethylene glycol) (PEG) side chains and cyanine5.5, a fluorescent probe,

Identifiers

PMID32864564
PMCPMC7451085
OpenAlexW2947391764

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.