Evidence map›Paper›PMID 32864533›Full record

ArticleCurrent opinion in physiology2020

Pancreatic β cell regeneration: To β or not to β.

Michelle A Guney, David S Lorberbaum, Lori Sussel

Open access · greenAbstract read
In one paragraph

Article in Current opinion in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Michelle A GuneyBarbara Davis Center for Diabetes, University of Colorado Anschutz Medical Center, Aurora CO 80045a.
David S LorberbaumBarbara Davis Center for Diabetes, University of Colorado Anschutz Medical Center, Aurora CO 80045a.
Lori SusselBarbara Davis Center for Diabetes, University of Colorado Anschutz Medical Center, Aurora CO 80045a.
University of Colorado Anschutz Medical Campus · US

Funding

Regulation of Pancreatic Islet Cell FateR01DK082590 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI LORI SUSSEL · 2009 to 2026
$7.3M
Intersection of signaling pathways and transcription factors regulating islet developmentR01DK118155 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI PAUL J GADUE, David Lorberbaum · 2018 to 2026
$4.9M
Defining the roles of Nkx2.2 and NeuroD in regulating islet cell fateU01DK072504 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI SUSSEL, LORI · 2005 to 2010
$3.2M
Single Cell Resolution Omics Analysis of T1D isletsUC4DK108101 · NIDDK · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI ANSONG, CHARLES K, SUSSEL, LORI · 2015 to 2015
$2.9M
Long non-coding RNAs in Islet Cell BiologyR01DK111405 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI SUSSEL, LORI · 2017 to 2020
$1.4M
NIDDK NIH HHS R01 DK082590NIDDK NIH HHS R01 DK111405NIDDK NIH HHS R01 DK118155NIDDK NIH HHS U01 DK072504NIDDK NIH HHS UC4 DK108101
6 · The paper itself

Abstract

Diabetes is a major worldwide health problem which results from the loss and/or dysfunction of pancreatic insulin-producing β cells in the pancreas. Therefore, there is great interest in understanding the endogenous capacity of β cells to regenerate under normal or pathological conditions, with the goal of restoring functional β cell mass in patients with diabetes. Here, we summarize the current status of β cell regeneration research, which has been broadly divided into three

Indexed as

beta cell regenerationbeta cellsDiabetesinsulinPancreatic islet

Identifiers

PMID32864533
PMCPMC7454996
OpenAlexW2987386461

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.