Evidence map›Paper›PMID 32864532›Full record

ArticleCurrent opinion in physiology2020

Drug discovery strategies for the identification of novel regulators of uterine contractility.

Shajila Siricilla, Chisom C Iwueke, Jennifer L Herington

Abstract read
In one paragraph

Article in Current opinion in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Shajila SiricillaDivision of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
Chisom C IwuekeDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA.
Jennifer L HeringtonDivision of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.

Funding

Pre-clinical studies to repurpose FDA-approved drugs for tocolytic useR01HD098213 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HERINGTON, JENNIFER L. · 2019 to 2023
$2.2M
Identifying Small Molecules that Regulate Uterine ContractionsR21HD088830 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HERINGTON, JENNIFER L. · 2017 to 2018
$435k
NICHD NIH HHS R01 HD098213NICHD NIH HHS R21 HD088830
6 · The paper itself

Abstract

Preterm birth and postpartum hemorrhage are the leading causes of neonatal and maternal morbidities worldwide, respectively. Current clinically utilized tocolytics and uterotonics to manage these obstetric conditions are limited due to their off-target effects and/or lack of efficacy. Thus, an ideal tocolytic or uterotonic would be uterine-selective with rapid onset and long-duration efficacy. Here, we discuss strategies for the discovery of new therapeutic targets and compounds that regulate uterine contractility with the aforementioned properties.

Identifiers

PMID32864532
PMCPMC7451233

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.