Evidence map›Paper›PMID 32864517›Full record

ArticleCurrent opinion in toxicology2019

Toxicant and teratogenic effects of prenatal alcohol.

Amanda H Mahnke, Amy M Adams, Andrew Z Wang, Rajesh C Miranda

Open access · greenAbstract read
In one paragraph

Article in Current opinion in toxicology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Extracellular Vesicles in CNS Developmental Disorders.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Amanda H MahnkeTexas A&M University Health Science Center, Department of Neuroscience and Experimental Therapeutics, Bryan, TX 77807 USA.
Amy M AdamsTexas A&M University Health Science Center, Department of Neuroscience and Experimental Therapeutics, Bryan, TX 77807 USA.
Andrew Z WangTexas A&M University Health Science Center, Department of Neuroscience and Experimental Therapeutics, Bryan, TX 77807 USA.
Rajesh C MirandaTexas A&M University Health Science Center, Department of Neuroscience and Experimental Therapeutics, Bryan, TX 77807 USA.
Texas A&M Health Science Center · USTexas A&M University · US

Funding

Optical Coherence Tomography to Study Effect of Poly - Drug Exposure on Fetal Brain DevelopmentR01HD086765 · NICHD · UNIVERSITY OF HOUSTON · PI Kirill V Larin, Irina Larina · 2016 to 2026
$5.0M
Prenatal microRNA neuro-therapeutics for fetal alcohol exposureR01AA024659 · NIAAA · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI MIRANDA, RAJESH C · 2016 to 2020
$1.8M
NIAAA NIH HHS R01 AA024659NICHD NIH HHS R01 HD086765
6 · The paper itself

Abstract

Prenatal alcohol exposure can result in growth, cognitive, and behavioral deficits due to the toxicant and teratogenic effects of alcohol. Alcohol is an unusual toxicant, because, unlike other toxicants, it is consumed and has biological effects in the millimolar range. Cerebral cortical development is particularly vulnerable to both alcohol's acute and long-term reprogramming effects. Recent evidence suggests that neuroinflammation may be a persistent result of prenatal alcohol exposure and that modes of cellular communication capable of carrying miRNAs, such as extracellular vesicles, may be an integral part of long-term changes to cellular communication and inflammation following in utero alcohol exposure.

Indexed as

cortical developmentextracellular vesiclesFetal alcohol spectrum disordersmiRNA

Identifiers

PMID32864517
PMCPMC7451635
OpenAlexW2969672148

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.