Evidence map›Paper›PMID 32864506›Full record

ArticleGene reports2020

Mitul Patel, Anoop Kumar, Dulari Jayawardena, Shubha Priyamvada, Arivarasu N Anbazhagan, Waddah A Alrefai, Ravinder K Gill, Pradeep K Dudeja, Seema Saksena

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gene reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Mitul PatelDivision of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago, Chicago, IL.
Anoop KumarJesse Brown VA Medical Center, University of Illinois at Chicago, Chicago, IL.
Dulari JayawardenaDivision of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago, Chicago, IL.
Shubha PriyamvadaDivision of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago, Chicago, IL.
Arivarasu N AnbazhaganDivision of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago, Chicago, IL.
Waddah A AlrefaiJesse Brown VA Medical Center, University of Illinois at Chicago, Chicago, IL.
Ravinder K GillDivision of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago, Chicago, IL.
Pradeep K DudejaJesse Brown VA Medical Center, University of Illinois at Chicago, Chicago, IL.
Seema SaksenaJesse Brown VA Medical Center, University of Illinois at Chicago, Chicago, IL.
University of Illinois Chicago · USJesse Brown VA Medical Center · US

Funding

Intestinal Anion Transporters: Function and RegulationR01DK054016 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DUDEJA, PRADEEP K · 1998 to 2022
$7.0M
Transporter Trafficking Mechanisms in Infectious DiarrheaR01DK092441 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DUDEJA, PRADEEP K · 2011 to 2020
$3.0M
Intestinal 5-HT Transporter: A novel therapeutic target for GI disordersR01DK098170 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GILL, RAVINDER K · 2014 to 2022
$3.0M
Probiotics:Potential Therapeutic Roles in DiarrheaR01DK081858 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DUDEJA, PRADEEP K · 2008 to 2017
$2.5M
Novel Role of DRA/SLC26A3 Downregulation in Gut Dysbiosis, Inflammation and InfectionR56DK092441 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DUDEJA, PRADEEP K · 2023 to 2023
$533k
BLRD Research Career Scientist Award ApplicationIK6BX005243 · VA · JESSE BROWN VA MEDICAL CENTER · PI ALREFAI, WADDAH A. · 2020 to 2025
–
A Novel Role of DRA in IBD PathogenesisIK2BX004719 · VA · JESSE BROWN VA MEDICAL CENTER · PI KUMAR, ANOOP · 2019 to 2023
–
Regulation of Intestinal Sodium Absorption in Health and DiseaseI01BX002867 · VA · JESSE BROWN VA MEDICAL CENTER · PI Seema Saksena · 2016 to 2026
–
Mechanisms of Regulation of Intestinal Cl Absorption in IBD Associated DiarrheaI01BX002011 · VA · JESSE BROWN VA MEDICAL CENTER · PI DUDEJA, PRADEEP K · 2013 to 2024
–
Regulation of Intestinal Bile Acid Absorption in Health and Cholesterol-Related DisordersI01BX000152 · VA · JESSE BROWN VA MEDICAL CENTER · PI Waddah A. Alrefai · 2009 to 2026
–
BLRD VA I01 BX000152BLRD VA I01 BX002011BLRD VA I01 BX002867BLRD VA IK2 BX004719BLRD VA IK6 BX005243NIDDK NIH HHS R01 DK054016NIDDK NIH HHS R01 DK081858NIDDK NIH HHS R01 DK092441NIDDK NIH HHS R01 DK098170NIDDK NIH HHS R56 DK092441
6 · The paper itself

Abstract

P-glycoprotein (Pgp/MDR1) serves as a biological barrier that protects intestinal epithelial cells (IECs) by transporting out xenobiotics and bacterial toxins. Decreased Pgp function and expression has been seen in mouse models of inflammatory colitis and also in patients with IBD. Pgp knockout mice spontaneously develop severe colitis, which is also seen in human patients with ulcerative colitis. However, whether Pgp is also altered in infectious colitis is not known.

Indexed as

C. rodentiumIBDinfecitious colitisinflammatory bowel diseaseMDR1P-glycoproteinPgp

Identifiers

PMID32864506
PMCPMC7451832
OpenAlexW2984296939

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.