ArticleApplied materials today2020
ECM-mimicking nanofibrous matrix coaxes macrophages toward an anti-inflammatory phenotype: Cellular behaviors and transcriptome analysis.
Article in Applied materials today, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Physicochemically-guided immunomodulatory biomaterials for regulating immune responses in rheumatoid arthritis.Materials today. Bio · 2026Article
- Mechanically Compliant, Precision-Porous Brain Implants Reduce the Foreign Body Reaction and Guide Regeneration.Advanced healthcare materials · 2026Article
- The janus-faced extracellular matrix remodeling in acute lung injury: a gatekeeper of macrophage localization and phenotype.Science China. Life sciences · 2026Article
- Assembly of bioinspired multifunctional microspheres for enhanced alveolar bone regeneration.Bioactive materials · 2026Article
- Immunomodulatory role of decellularized extracellular matrix in skin wound healing.Materials today. Bio · 2026Review
- Liposomal ellagic acid enhances the regenerative potential of ADMSC-laden nanofibrous PCL scaffolds in a rat model of spinal cord injury.Scientific reports · 2025Article
- Probiotic biofilm modified scaffolds for facilitating osteomyelitis treatment through sustained release of bacteriophage and regulated macrophage polarization.Materials today. Bio · 2025Article
- RAB13 regulates macrophage polarization in sepsis.Scientific reports · 2024Article
- From Poly(glycerol itaconate) Gels to Novel Nonwoven Materials for Biomedical Applications.Gels (Basel, Switzerland) · 2023Article
- Article
- Macrophage Related Chronic Inflammation in Non-Healing Wounds.Frontiers in immunology · 2021Review
- Host Response to Biomaterials for Cartilage Tissue Engineering: Key to Remodeling.Frontiers in bioengineering and biotechnology · 2021Review
- Emerging Nano/Micro-Structured Degradable Polymeric Meshes for Pelvic Floor Reconstruction.Nanomaterials (Basel, Switzerland) · 2020Review
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Authors and funding
5 authors.
Funding
Abstract
An in-depth understanding of biomaterial cues to selectively polarize macrophages is beneficial in the design of "immuno-informed" biomaterials that positively interact with the immune system to dictate a favorable macrophage response following implantation. Given the promising future of ECM-mimicking nanofibrous biomaterials in biomedical application, it is essential to elucidate how their intrinsic cues, especially the nanofibrous architecture, affect macrophages. In the present study, we evaluated how the nanofibrous architecture of a gelatin matrix modulated macrophage responses from the perspectives of cellular behaviors and a transcriptome analysis. In our results, the nanofibrous surface attenuated M1 polarization and down-regulated the inflammatory responses of macrophages compared with a smooth surface. Besides, the cell-material interaction was up-regulated and the adhered macrophages tended to maintain an original, non-polarized state on the nanofibrous matrix. Accordingly, whole transcriptome analysis revealed that nanofibrous architecture up-regulated the pathways related to ECM-receptor interaction and down-regulated pathways related to pro-inflammation. This study provides a panoramic view of the interaction between macrophages and nanofibers, and offers valuable information for the design of immunomodulatory ECM-mimicking biomaterials for tissue regeneration.
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