ArticleJournal of contextual behavioral science2020
Psychological flexibility mediates the relations between acute psychedelic effects and subjective decreases in depression and anxiety.
Article in Journal of contextual behavioral science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06620276 (Acceptance and Commitment Therapy in Patients With Alcohol Use Disorder and Comorbid Treatment-Resistant Depression Who Are Undergoing Ketamine Intervention), which is not on this map. Cited by 150 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Acceptance and Commitment Therapy in Patients With Alcohol Use Disorder and Comorbid Treatment-Resistant Depression Who Are Undergoing Ketamine Intervention: A Feasibility Study
Who cites it
150 citing papers in PubMed, 4 syntheses or guidelines pooled it, 353 citations in OpenAlex.
- Predictors of therapeutic response to psychedelic-assisted therapy: A systematic review.Journal of psychopharmacology (Oxford, England) · 2026Pooled it
- The effects of psilocybin on psychological distress in cancer patients: a systematic review and meta-analysis.BMC psychology · 2026Pooled it
- The effects of Lysergic Acid Diethylamide (LSD) on the Positive Valence Systems: A Research Domain Criteria (RDoC)-Informed Systematic Review.CNS drugs · 2023Pooled it
- Psychedelics, Mystical Experience, and Therapeutic Efficacy: A Systematic Review.Frontiers in psychiatry · 2022Pooled it
- Ayahuasca-assisted meaning reconstruction therapy as an early resource for bereavement: a non-randomized clinical trial.Scientific reports · 2025Trial
- Trial
- Meditating on psychedelics. A randomized placebo-controlled study of DMT and harmine in a mindfulness retreat.Journal of psychopharmacology (Oxford, England) · 2024Trial
- Psychological flexibility as a mechanism of change in psilocybin-assisted therapy for major depression: results from an exploratory placebo-controlled trial.Scientific reports · 2024Trial
- Trial
- The Watts Connectedness Scale: a new scale for measuring a sense of connectedness to self, others, and world.Psychopharmacology · 2022Trial
- Efficacy and safety of psilocybin-assisted treatment for major depressive disorder: Prospective 12-month follow-up.Journal of psychopharmacology (Oxford, England) · 2022Trial
- Psychedelic-assisted psychotherapy: Emerging paradigm.Canadian family physician Medecin de famille canadien · 2026Review
- Review
- Psilocybin modulates social behaviour in male and female mice in a time-dependent manner.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Psilocybin's effect on human brain synaptic plasticity.Translational psychiatry · 2026Article
- Mechanistic insights toward dissociating therapeutic from psychedelic effects: bridging the gap between psychedelic research and mental health care.Translational psychiatry · 2026Review
- Reward-tethered place cells support flexible magnitude coding and remapping in the hippocampus.bioRxiv : the preprint server for biology · 2026Article
- Psilocybin-Assisted Therapy for Adolescent Anorexia Nervosa: Clinical Considerations and Emerging Models of Care.Current psychiatry reports · 2026Review
- Facing trauma under the influence of psychedelics: A phenomenological study with Nova rave survivors.Journal of psychopharmacology (Oxford, England) · 2026Article
- The helioscope effect: A new framework for evaluating trauma-related memory processing in psychedelic experiences.Journal of psychopharmacology (Oxford, England) · 2026Article
90 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Prior research has shown that acute subjective psychedelic effects are associated with both spontaneous and intended changes in depression and anxiety. Psychedelics are also theorized to produce increases in psychological flexibility, which could explain decreases in depression and anxiety following a psychedelic experience. Therefore, the present cross-sectional survey study sought to examine whether psychological flexibility mediated the relationship between acute psychedelic experiences and spontaneous or intended changes in depression and anxiety among a large international sample of people who reported having used a psychedelic (n=985; male=71.6%; Caucasian/white=84.1%;
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.