ArticleScience bulletin2020
Impaired function of the suprachiasmatic nucleus rescues the loss of body temperature homeostasis caused by time-restricted feeding.
Article in Science bulletin, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- The suprachiasmatic nucleus: a central pacemaker for temporal coordination of energy metabolic homeostasis.Reviews in endocrine & metabolic disorders · 2026Review
- The suprachiasmatic nucleus regulates brown fat thermogenesis in male mice through an adrenergic receptor ADRB3-S100B signaling pathway.PLoS biology · 2025Article
- Time-restricted feeding reveals a role for neural respiratory clocks in optimizing daily ventilatory-metabolic coupling in mice.American journal of physiology. Endocrinology and metabolism · 2024Article
- Interorgan rhythmicity as a feature of healthful metabolism.Cell metabolism · 2024Review
- Disturbance of suprachiasmatic nucleus function improves cardiac repair after myocardial infarction by IGF2-mediated macrophage transition.Acta pharmacologica Sinica · 2023Article
- Time-restricted feeding entrains long-term behavioral changes through the IGF2-KCC2 pathway.iScience · 2022Article
- Circadian signatures of anterior hypothalamus in time-restricted feeding.F1000Research · 2022Article
- The burst of electrophysiological signals in the suprachiasmatic nucleus of mouse during the arousal detected by microelectrode arrays.Frontiers in bioengineering and biotechnology · 2022Article
- Protocol for setup and circadian analysis of inverted feeding in mice.STAR protocols · 2021Article
- Circadian Clock-Controlled Checkpoints in the Pathogenesis of Complex Disease.Frontiers in genetics · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
The suprachiasmatic nucleus (SCN) is the master circadian pacemaker that drives body temperature rhythm. Time-restricted feeding (TRF) has potential as a preventative or therapeutic approach against many diseases. The potential side effects of TRF remain unknown. Here we show that a 4-hour TRF stimulus in mice can severely impair body temperature homeostasis and can result in lethality. Nearly half of the mice died at 21 °C, and all mice died at 18 °C during 4-hour TRF. Moreover, this effect was modulated by the circadian clock and was associated with severe hypothermia due to loss of body temperature homeostasis, which is different from "torpor", an adaptive response under food deprivation. Disrupting the circadian clock by the SCN lesions or a non-invasive method (constant light) which disrupts circadian clock rescued lethality during TRF. Analysis of circadian gene expression in the dorsomedial hypothalamus (DMH) demonstrated that TRF reprograms rhythmic transcriptome in DMH and suppresses expression of genes, such as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.