Evidence map›Paper›PMID 32864156›Full record

ArticleMultiple sclerosis journal - experimental, translational and clinical

Non-infectious comorbidity in patients with multiple sclerosis: A national cohort study in Sweden.

Anna Castelo-Branco, Flaminia Chiesa, Camilla E Bengtsson, Sally Lee, Neil N Minton, Steve Niemcryk, Anders Lindholm, Mats Rosenlund, Fredrik Piehl, Scott Montgomery

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis journal - experimental, translational and clinical. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 5 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 5 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Neurogenic bladder in the multiple sclerosis population: A systematic review and meta-analysis of prevalence and a proposed evaluation algorithm.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Anna Castelo-BrancoClinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University Hospital and Örebro University, Örebro, Sweden.
Flaminia ChiesaClinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University Hospital and Örebro University, Örebro, Sweden.
Camilla E BengtssonReal-world Insights, IQVIA Nordics, Solna, Sweden.ORCID https://orcid.org/0000-0003-0157-3081
Sally LeeClinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University Hospital and Örebro University, Örebro, Sweden.
Neil N MintonClinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University Hospital and Örebro University, Örebro, Sweden.
Steve NiemcrykClinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University Hospital and Örebro University, Örebro, Sweden.
Anders LindholmCelgene Corporation, Summit, NJ, USA.
Mats RosenlundDepartment of Learning, Informatics, Management and Ethics, Karolinska Institutet, Stockholm, Sweden.
Fredrik PiehlDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Scott MontgomeryClinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University Hospital and Örebro University, Örebro, Sweden.
Örebro University · SEKarolinska Institutet · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundComorbidity is of significant concern in multiple sclerosis (MS). Few population-based studies have reported conditions occurring in MS after diagnosis, especially in contemporary cohorts.

objectiveTo explore incident comorbidity, mortality and hospitalizations in MS, stratified by age and sex.

methodsIn a Swedish population-based cohort study 6602 incident MS patients (aged ≥18 years) and 61,828 matched MS-free individuals were identified between 1 January 2008 and 31 December 2016, using national registers. Incidence rates (IRs) and incidence rate ratios (IRRs) with 95% CI were calculated for each outcome.

resultsIRs of cardiovascular disease (CVD) were higher among MS patients than MS-free individuals, (major adverse CVD: IRR 1.42; 95% CI 1.12-1.82; hemorrhagic/ischemic stroke: 1.46; 1.05-2.02; transient ischemic attack: 1.65; 1.09-2.50; heart failure: 1.55; 1.15-2.10); venous thromboembolism: 1.42; 1.14-1.77). MS patients also had higher risks of several non-CVDs such as autoimmune conditions (IRR 3.83; 3.01-4.87), bowel dysfunction (2.16; 1.86-2.50), depression (2.38; 2.11-2.68), and fractures (1.32; 1.19-1.47), as well as being hospitalized and to suffer from CVD-related deaths ((1.91; 1.00-3.65), particularly in females (3.57; 1.58-8.06)).

conclusionMS-patients experience a notable comorbidity burden which emphasizes the need for integrated disease management in order to improve patient care and long-term outcomes of MS.

Indexed as

cardiovascular diseasescohort studycomorbiditydepressionincidenceMultiple sclerosis

Identifiers

PMID32864156
PMCPMC7430080
OpenAlexW3049346082

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.