ArticleWorld journal of gastrointestinal oncology2020
Maspin subcellular expression in wild-type and mutant
Article in World journal of gastrointestinal oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Clinicopathological Implications of Maspin, CD8, and PD-L1 Expression in Liposarcomas.Current issues in molecular biology · 2025Article
- The paradoxical role of SERPINB5 in gastrointestinal cancers: oncogene or tumor suppressor?Molecular biology reports · 2025Review
- Significance of concurrent evaluation of HER2 gene amplification and p53 and Ki67 expression in gastric cancer tissues.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025Article
- Bioinformatic Identification of TP53 Gene Mutation Hotspots in Colorectal Cancer.International journal of molecular sciences · 2024Article
- TP53 mutations in Romanian patients with colorectal cancer.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2023Article
- Integrating the tumor-suppressive activity of Maspin with p53 in retuning the epithelial homeostasis: A working hypothesis and applicable prospects.Frontiers in oncology · 2022Review
- Characterization and clinical evaluation of microsatellite instability and loss of heterozygosity in tumor-related genes in gastric cancer.Oncology letters · 2021Article
- Review
- Identification of Stemness Characteristics Associated With the Immune Microenvironment and Prognosis in Gastric Cancer.Frontiers in oncology · 2021Article
- HER2 Heterogeneity in Gastric Cancer: A Comparative Study, Using Two Commercial Antibodies.Journal of oncology · 2020Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough the role of p53 in the evolution and prognosis of gastric cancer (GC) has been extensively examined, the exact mechanism of action is incompletely understood. In the last years, p53-target genes were supposed to be involved in the p53 pathway. One of them is the tumor-suppressor gene Maspin, which codifies the protein with the same name. Maspin activity depends on its subcellular localization. To our knowledge, the possible role of
aimTo evaluate the possible role of wild-type and mutated p53 in Maspin subcellular localization.
methodsThe present study included 266 consecutive patients with GC in which
resultsNone of the 266 cases showed mutations in exon 9. The rate of
conclusionDownregulated Maspin might be induced by mutations in exon 7 of the
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