Evidence map›Paper›PMID 32864035›Full record

ArticleNatural product communications2019

High-Resolution Structural Studies Elucidate Antiatherogenic and Anti-Inflammatory Properties of Peptides Designed to Mimic Amphipathic α-Helical Domains of Apolipoprotein A-I.

Vinod K Mishra, Gattadahalli M Anantharamaiah

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Natural product communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Apolipoprotein mimetics in cancer.Seminars in cancer biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Vinod K MishraNatural Science Division, Snead State Community College, Boaz, AL, USA.
Gattadahalli M AnantharamaiahDepartment of Medicine, University of Alabama at Birmingham, AL, USA.
Snead State Community College · USUniversity of Alabama at Birmingham · US

Funding

HDL and Cellular Repair MechanismsR01DK108836 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ANANTHARAMAIAH, G M, WHITE, C ROGER · 2016 to 2019
$1.3M
Cellular Lipids and Leukocyte FunctionR01GM115367 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ANANTHARAMAIAH, G M, WHITE, C ROGER · 2015 to 2018
$1.2M
NIDDK NIH HHS R01 DK108836NIGMS NIH HHS R01 GM115367
6 · The paper itself

Abstract

Peptides designed to mimic the antiatherogenic and anti-inflammatory properties of apolipoprotein A-I show that although lipid association is required, not all lipid-associating peptides exhibit these properties. Our studies of a series of peptides showed that peptides with aromatic residues at the center of the nonpolar face were able to interact with inflammatory lipids and inhibited inflammation, which resulted in the amelioration of several lipid-mediated disorders such as lesion development, tumor formation, and Alzheimer's plaque formation. The p

Indexed as

amphipathic α-helixapolipoprotein A-IHDLlipidlipoproteinNMRoxidized lipidpeptide

Identifiers

PMID32864035
PMCPMC7451220
OpenAlexW2947657240

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.