Evidence map›Paper›PMID 32864005›Full record

ArticleArchives of medical science : AMS2020

Long non-coding RNA HOTAIR regulates proliferation, migration and invasion of human cervical cancer cells by modulating expression of MAPK1.

Haiying Liu, Jing Liu, Guangzhang Zhao

RetractedOpen access · goldAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of medical science : AMS, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Haiying LiuDepartment of Oncology, Affiliated Hospital of Jining Medical University, Jining, Shandong Province, China.
Jing LiuCommunicable Disease Control Division in Qingdao Chengyang District Center for Disease Control and Prevention, Qingdao, Shandong Province, China.
Guangzhang ZhaoDepartment of Breast Surgery, Affiliated Hospital of Jining Medical University, Jining, Shandong Province, China.
Affiliated Hospital of Jining Medical University · CNQingdao Municipal Center for Disease Control and Prevention · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAccumulating evidence suggests that long non-coding RNAs (lncRNAs) are dysregulated in cancer cells and may be responsible for the development and progression of this disease. Herein, the role and therapeutic potential of aberrantly expressed lncRNA HOTAIR were investigated in cervical cancer. MATERIAL AND

methodsThe expression profile of the lncRNA HOTAIR was determined by quantitative RT-PCR. CCK-8 and colony formation assays were used for determination of cell viability. DAPI and annexin V/PI assays were used for detection of apoptosis. Wound healing and transwell assays were used to monitor cell migration and invasion.

resultsThe results showed that the expression of lncRNA HOTAIR was significantly (

conclusionsThese results indicate that lncRNA HOTAIR may prove to be an important therapeutic target for management of cervical cancer.

Indexed as

apoptosiscell invasioncell viabilitycervical cancerHOTAIRMAPK1

Identifiers

PMID32864005
PMCPMC7444711
OpenAlexW2923435945

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.