Evidence map›Paper›PMID 32863951›Full record

ArticleTheranostics2020

HDAC3 inhibition ameliorates ischemia/reperfusion-induced brain injury by regulating the microglial cGAS-STING pathway.

Yajin Liao, Jinbo Cheng, Xiangxi Kong, Shuoshuo Li, Xiaoheng Li, Meijuan Zhang, He Zhang, Tianli Yang, Yuan Dong, Jun Li and 2 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 194 papers.

0numbers the graph read from it
0cells of the map it votes in
194citing papers in PubMed
11.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

194 citing papers in PubMed, 321 citations in OpenAlex.

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  13. [Mechanisms of cGAS-STING signaling pathway mediated neuroinflammation in central nervous system and their therapeutic implications].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2026
    Review
  14. [Thymosin β4 inhibits pyroptosis in BV2 microglial cells: a mechanistic studyZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026
    Article
  15. Lipid metabolism, microglia, and stroke.Neural regeneration research · 2026
    Article
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134 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Yajin LiaoThe Brain Science Center, Beijing Institute of Basic Medical Sciences, No. 27 Taiping Road, Haidian District, Beijing 100850, China.
Jinbo ChengThe Brain Science Center, Beijing Institute of Basic Medical Sciences, No. 27 Taiping Road, Haidian District, Beijing 100850, China.
Xiangxi KongThe Brain Science Center, Beijing Institute of Basic Medical Sciences, No. 27 Taiping Road, Haidian District, Beijing 100850, China.
Shuoshuo LiThe Brain Science Center, Beijing Institute of Basic Medical Sciences, No. 27 Taiping Road, Haidian District, Beijing 100850, China.
Xiaoheng LiThe Brain Science Center, Beijing Institute of Basic Medical Sciences, No. 27 Taiping Road, Haidian District, Beijing 100850, China.
Meijuan ZhangDepartment of Neurology, Affiliated Drum Tower Hospital of Nanjing University, Medical School, Nanjing 210008, China.
He ZhangDepartment of Neurology, Affiliated Drum Tower Hospital of Nanjing University, Medical School, Nanjing 210008, China.
Tianli YangBeijing Institute for Brain Disorders, Capital Medical University, Beijing, 100069, China.
Yuan DongDepartment of Biochemistry, Medical College, Qingdao University, Qingdao, Shandong, 266071, China.
Jun LiBeijing Institute for Brain Disorders, Capital Medical University, Beijing, 100069, China.
Yun XuDepartment of Neurology, Affiliated Drum Tower Hospital of Nanjing University, Medical School, Nanjing 210008, China.
Zengqiang YuanThe Brain Science Center, Beijing Institute of Basic Medical Sciences, No. 27 Taiping Road, Haidian District, Beijing 100850, China.
Chinese Institute for Brain Research · CNCapital Medical University · CNMinzu University of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsBrainBrain InjuriesBrain IschemiaCell LineCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseDNA, MitochondrialHEK293 CellsHistone Deacetylase 3Histone DeacetylasesHumansInfarction, Middle Cerebral ArteryInflammationMembrane ProteinsMice, KnockoutMicrogliacGAS protein, mouseCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseDNA, MitochondrialHistone Deacetylase 3Histone DeacetylasesMembrane ProteinsNucleotidyltransferasesSting1 protein, mouseSTING ProteincGASHDAC3Ischemia/reperfusionMicrogliaNeuroinflammation

Identifiers

PMID32863951
PMCPMC7449914
OpenAlexW3046747465

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.