Evidence map›Paper›PMID 32863942›Full record

ArticleTheranostics2020

Pharmacological depletion of microglia and perivascular macrophages prevents Vascular Cognitive Impairment in Ang II-induced hypertension.

Danielle Kerkhofs, Britt T van Hagen, Irina V Milanova, Kimberly J Schell, Helma van Essen, Erwin Wijnands, Pieter Goossens, W Matthijs Blankesteijn, Thomas Unger, Jos Prickaerts and 3 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 70 citations in OpenAlex.

  1. Article
  2. Targeting the 5-HTCell & bioscience · 2026
    Article
  3. Review
  4. Current updates on latest basic research of scientific relevance in hypertensive dementia.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Immune Mechanisms in Hypertension.Hypertension (Dallas, Tex. : 1979) · 2024
    Review
  16. Article
  17. CNS resident macrophages enhance dysfunctional angiogenesis and circulating monocytes infiltration in brain arteriovenous malformation.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  18. Hypertension, Neurodegeneration, and Cognitive Decline.Hypertension (Dallas, Tex. : 1979) · 2024
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Danielle KerkhofsDepartment of Neurology, Maastricht University Medical Center, 6202AZ, Maastricht, The Netherlands.
Britt T van HagenDepartment of Psychiatry and Neuropsychology, Maastricht University, 6200MD, Maastricht, The Netherlands.
Irina V MilanovaDepartment of Pharmacology and Toxicology, Maastricht University, 6200MD, Maastricht, The Netherlands.
Kimberly J SchellDepartment of Pathology, Maastricht University, Maastricht, 6200MD, The Netherlands.
Helma van EssenCARIM - School for Cardiovascular Diseases, Maastricht University, 6200MD, The Netherlands.
Erwin WijnandsDepartment of Pathology, Maastricht University, Maastricht, 6200MD, The Netherlands.
Pieter GoossensDepartment of Pathology, Maastricht University, Maastricht, 6200MD, The Netherlands.
W Matthijs BlankesteijnDepartment of Pharmacology and Toxicology, Maastricht University, 6200MD, Maastricht, The Netherlands.
Thomas UngerCARIM - School for Cardiovascular Diseases, Maastricht University, 6200MD, The Netherlands.
Jos PrickaertsDepartment of Psychiatry and Neuropsychology, Maastricht University, 6200MD, Maastricht, The Netherlands.
Erik A BiessenDepartment of Pathology, Maastricht University, Maastricht, 6200MD, The Netherlands.
Robert J van OostenbruggeDepartment of Neurology, Maastricht University Medical Center, 6202AZ, Maastricht, The Netherlands.
Sébastien FoulquierDepartment of Neurology, Maastricht University Medical Center, 6202AZ, Maastricht, The Netherlands.
Maastricht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Angiotensin IIAnimalsBlood-Brain BarrierBlood PressureBrainCognitive DysfunctionDisease Models, AnimalEnzyme InhibitorsHypertensionMacrophagesMaleMiceMicrogliaOrganic ChemicalsAngiotensin IIEnzyme InhibitorsOrganic ChemicalsPLX5622

Identifiers

PMID32863942
PMCPMC7449902
OpenAlexW3044493771

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.