Evidence map›Paper›PMID 32863891›Full record

ArticleJournal of drug delivery science and technology2020

Manufacturing strategies to develop amorphous solid dispersions: An overview.

Nicole Mendonsa, Bjad Almutairy, Venkata Raman Kallakunta, Sandeep Sarabu, Priyanka Thipsay, Suresh Bandari, Michael A Repka

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of drug delivery science and technology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

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  5. Polymers Enhance Chlortetracycline Hydrochloride Solubility.International journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nicole MendonsaDepartment of Pharmaceutics and Drug Delivery, The University of Mississippi, Oxford, MS, 38677, United States.
Bjad AlmutairyDepartment of Pharmaceutics and Drug Delivery, The University of Mississippi, Oxford, MS, 38677, United States.
Venkata Raman KallakuntaDepartment of Pharmaceutics and Drug Delivery, The University of Mississippi, Oxford, MS, 38677, United States.
Sandeep SarabuDepartment of Pharmaceutics and Drug Delivery, The University of Mississippi, Oxford, MS, 38677, United States.
Priyanka ThipsayDepartment of Pharmaceutics and Drug Delivery, The University of Mississippi, Oxford, MS, 38677, United States.
Suresh BandariDepartment of Pharmaceutics and Drug Delivery, The University of Mississippi, Oxford, MS, 38677, United States.
Michael A RepkaDepartment of Pharmaceutics and Drug Delivery, The University of Mississippi, Oxford, MS, 38677, United States.

Funding

Center of Research Excellence in Natural Products Neuroscience (CORE-NPN)P20GM104932 · NIGMS · UNIVERSITY OF MISSISSIPPI · PI MAJUMDAR, SOUMYAJIT · 2012 to 2016
$10.0M
NIGMS NIH HHS P20 GM104932
6 · The paper itself

Abstract

Since the past several decades, poor water solubility of existing and new drugs in the pipeline have remained a challenging issue for the pharmaceutical industry. Literature describes several approaches to improve the overall solubility, dissolution rate, and bioavailability of drugs with poor water solubility. Moreover, the development of amorphous solid dispersion (SD) using suitable polymers and methods have gained considerable importance in the recent past. In the present review, we attempt to discuss the important and industrially scalable thermal strategies for the development of amorphous SD. These include both solvent (spray drying and fluid bed processing) and fusion (hot melt extrusion and KinetiSol®) based techniques. The current review also provides insights into the thermodynamic properties of drugs, their polymer miscibility and solubility, and their molecular dynamics to develop stable and more efficient amorphous SD.

Indexed as

Amorphous solid dispersionFluid bed technologyHot melt extrusionKinetiSol® technologySpray drying

Identifiers

PMID32863891
PMCPMC7453425

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.