Evidence map›Paper›PMID 32863744›Full record

ArticleThe Malaysian journal of medical sciences : MJMS2020

In Vitro Antimalarial and Toxicological Activities of

Nik Nor Imam Nik Mat Zin, Mira Nabila Mohamad, Keusar Roslan, Sazeli Abdul Wafi, Nurul I'zaaz Abdul Moin, Azamuddin Alias, Yusmazura Zakaria, Nurhidanatasha Abu-Bakar

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Malaysian journal of medical sciences : MJMS, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Phytochemical Profiling and Biological Activities ofPlants (Basel, Switzerland) · 2023
    Review
  4. Fractions 14 and 36K of Metabolite ExtractInfection and drug resistance · 2023
    Article
  5. Article
  6. Antimalarial Efficacy of Hydromethanolic Root Extract and Solvent Fractions ofEvidence-based complementary and alternative medicine : eCAM · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Nik Nor Imam Nik Mat ZinSchool of Health Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
Mira Nabila MohamadSchool of Health Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
Keusar RoslanSchool of Health Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
Sazeli Abdul WafiPengiran Anak Puteri Rashidah Sa'adatul Bolkiah Institute of Health Sciences, Universiti Brunei Darussalam, Brunei Darussalam.
Nurul I'zaaz Abdul MoinDepartment of Biomedical Sciences, Universiti Islam Antarabangsa Malaysia, Kuantan, Pahang, Malaysia.
Azamuddin AliasDepartment of Biomedical Sciences, Universiti Islam Antarabangsa Malaysia, Kuantan, Pahang, Malaysia.
Yusmazura ZakariaSchool of Health Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
Nurhidanatasha Abu-BakarSchool of Health Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
Universiti Sains Malaysia · MYInternational Islamic University Malaysia · MYUniversiti Brunei Darussalam · BN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe spread of

methodsThe extracts were assessed for the antimalarial potential using a malarial SYBR Green I fluorescence-based (MSF) assay, while the toxicity was screened by using brine shrimp lethality test (BSLT), haemolytic assay, and cytotoxicity assay against normal embryo fibroblast cell line (NIH/3T3) and normal kidney epithelial cell line (Vero).

resultsThe acetone extract showed the highest antimalarial activity (50% inhibitory concentration, IC

conclusionTaken together with satisfactory selectivity index (SI) values, the acetone and methanol extracts of

Indexed as

3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide assayantimalarial activitybrine shrimp lethality testhaemolytic assaymalarial SYBR Green I fluorescencebased assayQuercus infectoriatoxicological activity

Identifiers

PMID32863744
PMCPMC7444841
OpenAlexW3061533752

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.