Evidence map›Paper›PMID 32863594›Full record

ArticleParticle & particle systems characterization : measurement and description of particle properties and behavior in powders and other disperse systems2019

Copper Sulfide Nanodisks and Nanoprisms for Photoacoustic Ovarian Tumor Imaging.

Junxin Wang, Su-Wen Hsu, Natalia Gonzalez-Pech, Anamik Jhunjhunwala, Fang Chen, Ali Hariri, Vicki Grassian, Andrea Tao, Jesse V Jokerst

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Particle & particle systems characterization : measurement and description of particle properties and behavior in powders and other disperse systems, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. The Coppery Age: Copper (Cu)-Involved Nanotheranostics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Junxin WangDepartment of Nano Engineering, University of California San Diego, La Jolla, CA 92093, USA.
Su-Wen HsuDepartment of Nano Engineering, University of California San Diego, La Jolla, CA 92093, USA.
Natalia Gonzalez-PechDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093, USA.
Anamik JhunjhunwalaDepartment of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA.
Fang ChenMaterial Science and Engineering Program, University of California San Diego, La Jolla, CA 92093, USA.
Ali HaririDepartment of Nano Engineering, University of California San Diego, La Jolla, CA 92093, USA.
Vicki GrassianDepartment of Nano Engineering, University of California San Diego, La Jolla, CA 92093, USA.
Andrea TaoDepartment of Nano Engineering, University of California San Diego, La Jolla, CA 92093, USA.
Jesse V JokerstDepartment of Nano Engineering, University of California San Diego, La Jolla, CA 92093, USA.
University of California San Diego · US

Funding

Therapeutic Drug Monitoring with a Wearable Ultrasound-based SensorDP2HL137187 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JOKERST, JESSE VINCENT · 2016 to 2019
$2.7M
A Therapeutic Tool for Ultrasound-Guided Stem Cell TherapyR00HL117048 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JOKERST, JESSE VINCENT · 2015 to 2017
$747k
Vevo LAZR Photoacoustic Imaging SystemS10OD021821 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HALL, DAVID J · 2016 to 2016
$594k
JEOL JEM-1400Plus Transmission Electron MicroscopeS10OD023527 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FARQUHAR, MARILYN GIST · 2017 to 2017
$579k
A Therapeutic Tool for ULtrasound-Guided Stem Cell TherapyK99HL117048 · NHLBI · STANFORD UNIVERSITY · PI JOKERST, JESSE VINCENT · 2014 to 2015
$265k
NHLBI NIH HHS DP2 HL137187NHLBI NIH HHS K99 HL117048NHLBI NIH HHS R00 HL117048NIH HHS S10 OD021821NIH HHS S10 OD023527
6 · The paper itself

Abstract

Transvaginal ultrasound is widely used for ovarian cancer screening but has a high false positive rate. Photoacoustic imaging provides additional optical contrast to supplement ultrasound and might be able to improve the accuracy of screening. Here, we report two copper sulfide (CuS) nanoparticles types (nanodisks and triangular nanoprisms) as the photoacoustic contrast agents for imaging ovarian cancer. Both CuS nanoprisms and nanodisks were ~6 nm thick and ~26 nm wide and were coated with poly(ethylene glycol) to make them colloidally stable in phosphate buffered saline (PBS) for at least 2 weeks. The CuS nanodisks and nanoprisms revealed strong localized surface plasmon resonances with peak maxima at 1145 nm and 1098 nm, respectively. Both nanoparticles types had strong and stable photoacoustic intensity with detection limits below 120 pM. The circular CuS nanodisk remained in the circulation of nude mice (n=4) and xenograft 2008 ovarian tumors (n=4) 17.9-fold and 1.8-fold more than the triangular nanoprisms, respectively. Finally, the photoacoustic intensity of the tumors from the mice (n=3) treated with CuS nanodisks was 3.0-fold higher than the baseline. The tumors treated with nanodisks had a characteristic peak at 920 nm in the spectrum to potentially differentiate the tumor from adjacent tissues.

Indexed as

copper sulfide nanoparticlesovarian cancerPhotoacoustic imaging

Identifiers

PMID32863594
PMCPMC7451243
OpenAlexW2948982564

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.