Evidence map›Paper›PMID 32863592›Full record

ArticleJournal of sol-gel science and technology2019

Synthesis of silica-alginate nanoparticles and their potential application as pH-responsive drug carriers.

Xin Fan, Roman C Domszy, Naiping Hu, Arthur J Yang, Jeff Yang, Allan E David

Abstract read
In one paragraph

Article in Journal of sol-gel science and technology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xin FanDepartment of Chemical Engineering, Auburn University, Auburn, AL.
Roman C DomszyIndustrial Science & Technology Network, Inc., Lancaster, PA.
Naiping HuLynthera Corporation, Lancaster, PA.
Arthur J YangLynthera Corporation, Lancaster, PA.
Jeff YangLynthera Corporation, Lancaster, PA.
Allan E DavidDepartment of Chemical Engineering, Auburn University, Auburn, AL.

Funding

Ophthalmic drug delivery using a multi-layer contact lens design that enables targeting, constant-rate release and failure protectionR44EY026850 · NEI · LYNTHERA CORPORATION · PI YANG, ARTHUR · 2018 to 2020
$1.7M
NEI NIH HHS R44 EY026850
6 · The paper itself

Abstract

Composite silica-alginate nanoparticles were prepared via silica sol-gel technique using a water-in-oil microemulsion system. In our system, cyclohexane served as the bulk oil phase into which aqueous solutions of sodium alginate were dispersed as droplets that confined nanoparticle formation after addition of tetraethylorthosilicate (TEOS). Our studies showed that much of the particle growth is completed within the first 24 hours and reaction times up to 120 hours only resulted in an additional 5% increase in particle diameter. Average particle size was found to decrease with increasing water-to-surfactant molar ratio (

Indexed as

microemulsionpH-responsive drug releaserhodamine Bsilica-alginate nanoparticlessol-gel encapsulation

Identifiers

PMID32863592
PMCPMC7451248

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.