Evidence map›Paper›PMID 32863588›Full record

ArticleSensors and actuators. B, Chemical2020

A Low-Cost Nanomaterial-based Electrochemical Immunosensor on Paper for High-Sensitivity Early Detection of Pancreatic Cancer.

K Sudhakara Prasad, Xiyue Cao, Ning Gao, Qijie Jin, Sharma T Sanjay, Gilberto Henao-Pabon, XiuJun Li

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sensors and actuators. B, Chemical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 139 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

K Sudhakara PrasadDepartment of Chemistry & Biochemistry, University of Texas at El Paso, Texas, USA.
Xiyue CaoDepartment of Chemistry & Biochemistry, University of Texas at El Paso, Texas, USA.
Ning GaoDepartment of Chemistry & Biochemistry, University of Texas at El Paso, Texas, USA.
Qijie JinDepartment of Chemistry & Biochemistry, University of Texas at El Paso, Texas, USA.
Sharma T SanjayDepartment of Chemistry & Biochemistry, University of Texas at El Paso, Texas, USA.
Gilberto Henao-PabonBiomedical Engineering, Border Biomedical Research Center, and Environmental Science & Engineering, University of Texas at El Paso, USA.
XiuJun LiDepartment of Chemistry & Biochemistry, University of Texas at El Paso, Texas, USA.
The University of Texas at El Paso · USNanjing Tech University · CNQingdao University · CN

Funding

Technologies and Resources CoreU54MD007593 · NIMHD · MEHARRY MEDICAL COLLEGE · PI ADUNYAH, SAMUEL EVANS · 2012 to 2018
$24.7M
Grafting DNA Codes on Paper for Rapid, Low-Cost, and Sensitive Meningitis DiagnosSC2GM105584 · NIGMS · UNIVERSITY OF TEXAS EL PASO · PI LI, XIUJUN · 2013 to 2015
$438k
Design of Point of Care Device for the Rapid Diagnosis of PertussisR21AI107415 · NIAID · UNIVERSITY OF TEXAS EL PASO · PI DOMINGUEZ, DELFINA C, LI, XIUJUN · 2015 to 2016
$405k
NIAID NIH HHS R21 AI107415NIGMS NIH HHS SC2 GM105584NIMHD NIH HHS U54 MD007593
6 · The paper itself

Abstract

Due to the lack of specific early detection methods for pancreatic cancer, it usually goes undetected until it is advanced. By employing paper-based electrodes (PPE), herein we for the first time developed a disposable low-cost paper-based immunosensor for rapid early quantitative detection of pancreatic cancer with a new biomarker, pseudopodium-enriched atypical kinase one, SGK269 (PEAK1). The immunosensor was constructed by fabricating PPEs immobilized with the versatile nanomaterial graphene oxide for the incorporation of antibodies to form an immunosensing platform, without the need of complicated surface modification. After it was confirmed that the PPEs exhibited excellent electrochemical properties, a sandwich-type electrochemical immunosensor was subsequently constructed by employing graphene oxide layers immobilized with anti-PEAK1, and the antibody conjugated with gold nanoparticles (AuNPs-tagged-Anti PEAK1). Further, spectral and surface characteristic studies confirmed the formation of the immunosensing platform. The immunosensor for PEAK1 exhibited a wide linear range between 10 pg mL

Indexed as

Electrochemical BiosensorGraphene oxideNanomaterial-based immunosensingPancreatic cancerPaper-based microfluidic devicesPEAK 1

Identifiers

PMID32863588
PMCPMC7453835
OpenAlexW2991651137

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.