Evidence map›Paper›PMID 32863410›Full record

ArticleGhana medical journal2020

Self-reported adherence to highly active antiretroviral therapy in a tertiary hospital in Nigeria.

Ekiuwa V Eribo, Omokhoa A Adeleye

Abstract read
In one paragraph

Article in Ghana medical journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
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1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ekiuwa V EriboDepartment of Pharmacy, University of Benin Teaching Hospital, Benin City, Nigeria.
Omokhoa A AdeleyeDepartment of Community Health, University of Benin Teaching Hospital, Benin City, Nigeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNon-adherence to highly active antiretroviral therapy (HAART) favours drug resistance and wastes resources. These have negative implications for personal and public health.

objectiveTo assess adherence levels, the associated factors and its association with increase in CD4 cell count in people living with HIV (PLHIVs).

methodsIn a cross-sectional survey, systematically selected adult PLHIVs attending a tertiary hospital in Nigeria self-reported their 28-day adherence to HAART and reasons for missing doses using an interviewer-administered questionnaire. Their 6-month difference in CD4 cell count was also assessed.

resultsThe participants totalled 425. Their mean age was 38.6 (SD, 10.1) years and 309 (72.7%) had secondary or tertiary education. The 28-day mean adherence level was 96.8% (SD, 7.9%) and 354 (83.3%) participants had optimal adherence (≥ 95%). Socio-demographic characteristics, side effects and having human reminders were not associated with adherence level, but 100% adherence level since placement on HAART was positively associated with a 6-month increase in CD4 cell count (

conclusionMean adherence was high and the majority of participants had optimal adherence. "Never missing a dose" was associated with improved CD4 cell counts, indicating better prognosis. Socio-demographic factors, side effects and human reminders were not associated with an increase in adherence. However, as there is no evidence that adherence improvement measures are detrimental, their use is still recommended.

fundingNone declared.

Indexed as

Antiretroviral Therapy, Highly ActiveMedication AdherenceSelf ReportAdultCD4 Lymphocyte CountCross-Sectional StudiesFemaleHIV InfectionsHumansMaleMiddle AgedNigeriaTertiary Care Centersdrug resistanceHAARTHIVMedication adherenceNigeria

Identifiers

PMID32863410
PMCPMC7445700

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.