Evidence map›Paper›PMID 32863295›Full record

ArticleJournal of atherosclerosis and thrombosis2021

Apolipoprotein A2 Isoforms in Relation to the Risk of Myocardial Infarction: A Nested Case-Control Analysis in the JPHC Study.

Tomomi Kihara, Kazumasa Yamagishi, Kazufumi Honda, Ai Ikeda, Hiroshi Yatsuya, Isao Saito, Yoshihiro Kokubo, Taiki Yamaji, Taichi Shimazu, Norie Sawada and 4 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of atherosclerosis and thrombosis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. [Quantitative analysis of lipid metabolism-related differential proteins in patients with alcoholic liver disease].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2023
    Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 3 countries.

Tomomi KiharaPublic Health, Department of Social Medicine, Osaka University Graduate School of Medicine.
Kazumasa YamagishiDepartment of Public Health Medicine, Faculty of Medicine, and Health Services Research and Development Center, University of Tsukuba.
Kazufumi HondaDepartment of Biomarkers for Early Detection of Cancer, National Cancer Center Research Institute.
Ai IkedaDepartment of Public Health, Juntendo University Graduate School of Medicine.
Hiroshi YatsuyaDepartment of Public Health, Fujita Health University School of Medicine.
Isao SaitoDepartment of Public Health and Epidemiology, Faculty of Medicine, Oita University.
Yoshihiro KokuboDepartment of Preventive Cardiology, National Cerebral and Cardiovascular Center.
Taiki YamajiEpidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center.
Taichi ShimazuEpidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center.
Norie SawadaEpidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center.
Motoki IwasakiEpidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center.
Hiroyasu IsoPublic Health, Department of Social Medicine, Osaka University Graduate School of Medicine.
Shoichiro TsuganeEpidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center.
JPHC Study Group
Prevention Group · USHealth Services Research & Development · USFujita Health University · JPJuntendo University · JPNational Cerebral and Cardiovascular Center · JPOita University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThe fact that low concentrations of high-density lipoprotein cholesterol are associated with the risk of cardiovascular disease is well known, but high-density lipoprotein metabolism has not been fully understood. Apolipoprotein A2 (ApoA2) is the second-most dominant apolipoprotein of high-density lipoprotein. We tested the hypothesis that ApoA2 isoforms are inversely associated with myocardial infarction.

methodsWe measured the plasma levels of three ApoA2 isoforms (ApoA2-ATQ/ATQ, ApoA2-ATQ/AT, ApoA2-AT/AT) in nested case-control study samples of 1:2 from the Japan Public Health-Center-based Study (JPHC Study): 106 myocardial infarction incidence cases and 212 controls.

resultsApoA2-AT/AT was inversely associated with risk of myocardial infarction, in a matched model (OR, 2.78; 95% CI, 1.26-6.09 for lowest compared with the highest quartile), but its association was attenuated after adjustment for smoking only (OR=2.13; 95% CI, 0.91-4.97) or drinking only (OR=2.11; 0.91-4.89), and the multivariable OR was 1.20 (95% CI, 0.41-3.57). Neither ApoA2-ATQ/ATQ nor ApoA2-ATQ/AT was associated with the risk of myocardial infarction.

conclusionsOur nested case-control study did not show a significant association of ApoA2 isoforms with a risk of myocardial infarction.

Indexed as

Apolipoprotein A-IICase-Control StudiesCohort StudiesFemaleHumansIncidenceJapanMaleMiddle AgedMyocardial InfarctionProtein IsoformsRisk FactorsAPOA2 protein, humanApolipoprotein A-IIProtein IsoformsApolipoprotein A-IIAtherosclerosisCoronary heart diseaseC-terminusHDL

Identifiers

PMID32863295
PMCPMC8193784
OpenAlexW3082607041

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.