ReviewTrends in neurosciences2020
Neurodevelopmental Optimization after Early-Life Adversity: Cross-Species Studies to Elucidate Sensitive Periods and Brain Mechanisms to Inform Early Intervention.
Review in Trends in neurosciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
106 citing papers in PubMed.
- Does immediate skin-to-skin contact at caesarean sections promote uterine contraction and recovery of the maternal blood haemoglobin levels? A randomized clinical trial.Nursing open · 2023Trial
- Loss of pleasure (Anhedonia): A sex-dependent, cross-species consequence of unpredictable signals to the perinatal brain.Neurobiology of stress · 2026Article
- Type and developmental timing of childhood adversity predicts psychopathology symptoms in a South African birth cohort.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Barriers and Facilitators to Skin-to-Skin Contact After Caesarean Section: A Qualitative Study.Healthcare (Basel, Switzerland) · 2026Article
- Distinct spatial associations of adversity with hippocampal macro- and microstructure in early adolescence.bioRxiv : the preprint server for biology · 2026Article
- Enigma of autism regression mechanistic pathways, clinical phenotypes, and early intervention implications.World journal of clinical pediatrics · 2026Review
- Early-life adversity in rodents: Experimental design is of the essence.Neurobiology of stress · 2026Article
- White matter reflects the childhood exposome.bioRxiv : the preprint server for biology · 2026Article
- Physical-Digital and social-nonsocial extracurricular engagement: differential effects on brain development and psychological outcomes in children.Translational psychiatry · 2026Article
- Unpredictable maternal signals and developmental profiles of child executive function from infancy to early childhood.Developmental cognitive neuroscience · 2026Article
- Early life adversity impairs visually evoked innate defensive behaviors via oxytocin signaling.Communications biology · 2026Article
- Sex and Stress Govern the Function and Innervation of a Basolateral Amygdala to Nucleus Accumbens Corticotropin-Releasing Hormone/GABA-Expressing Projection.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- The Cognitive-Affective Social Processing and Emotion Regulation (CASPER) model.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Investigating hierarchical critical periods in human neurodevelopment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Early life shifts in cortical inhibitory-excitatory balance underlies sensitive periods and skill development.Frontiers in cellular neuroscience · 2026Article
- Unpredictability is a childhood adversity that contributes to mental health problems.Nature. Mental health · 2026Article
- Social Determinants of Health, the developing brain, and risk and resilience for psychopathology.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Early life social isolation stress and pain vulnerability: unraveling neuroimmune mechanisms and central sensitization.Frontiers in pharmacology · 2026Review
- Evaluating the Effectiveness of a School-Based Mental Health Training Programme: The Transformative, Resilient, Youth-Led (TRY) Gym.Healthcare (Basel, Switzerland) · 2025Article
- Associations between early life adversity and the development of gray matter macrostructure and microstructure.Psychological medicine · 2025Article
46 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Human brain development is influenced by early-life experiences, particularly during sensitive periods, with impact on cognitive and emotional outcomes. Understanding how the timing and nature of such experiences (including adversity, trauma, and enrichment) govern their influence on brain organization is crucial for harnessing key environmental factors early in life to enhance brain development. Here we synthesize findings from human and animal studies focusing on sensitive periods and their regional and circuit specificity and highlight the challenge and power of such cross-species approaches in informing the 'next steps' to optimize cognitive and emotional health in developing children. We propose designs for neurodevelopmental optimization research programs utilizing randomized enhancement trials in early childhood to inform public health strategies on prevention and early intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.