Evidence map›Paper›PMID 32863043›Full record

ArticleTrends in neurosciences2020

The Jekyll and Hyde of TREM2.

Javier Rueda-Carrasco, Soyon Hong

Abstract readComment
PubMed Publisher
In one paragraph

Article in Trends in neurosciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Microglial INPP5D limits plaque formation and glial reactivity in the PSAPP mouse model of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023
    Article
  2. Microglia in Alzheimer's Disease: a Key Player in the Transition Between Homeostasis and Pathogenesis.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022
    Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Javier Rueda-CarrascoUK Dementia Research Institute at University College London, Institute of Neurology, Gower Street, London WC1E 6BT, UK.
Soyon HongUK Dementia Research Institute at University College London, Institute of Neurology, Gower Street, London WC1E 6BT, UK. Electronic address: soyon.hong@ucl.ac.uk.
UK Dementia Research Institute · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In a recent paper, Gratuze et al. demonstrated a putative neuroprotective role of a key Alzheimer risk variant, TREM2

Indexed as

Alzheimer DiseaseGliosisAnimalsDisease Models, AnimalMembrane GlycoproteinsMiceMicrogliaReceptors, ImmunologicMembrane GlycoproteinsReceptors, ImmunologicTrem2 protein, mouseAlzheimer’s diseasemicrogliatauopathyTREM2

Identifiers

PMID32863043
OpenAlexW3082724740

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.