Evidence map›Paper›PMID 32862984›Full record

SynthesisJournal de medecine vasculaire2020

Association between D-Dimer levels and mortality in patients with coronavirus disease 2019 (COVID-19): a systematic review and pooled analysis.

M Sakka, J M Connors, G Hékimian, I Martin-Toutain, B Crichi, I Colmegna, D Bonnefont-Rousselot, D Farge, C Frere

Open access · bronzeAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal de medecine vasculaire, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
1.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 86 citations in OpenAlex.

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  20. COVID19 biomarkers: What did we learn from systematic reviews?Frontiers in cellular and infection microbiology · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 3 countries.

M SakkaAssistance Publique Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Department of Metabolic Biochemistry, 75013 Paris, France.
J M ConnorsHematology Division, Brigham and Women's Hospital, Dana Farber Cancer Institute, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
G HékimianAssistance Publique Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Intensive Care Unit, 75013 Paris, France.
I Martin-ToutainAssistance Publique Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Department of Hematology, 75013 Paris, France.
B CrichiAssistance Publique Hôpitaux de Paris, Saint-Louis Hospital, Department of Internal Medicine, Autoimmune and Vascular Disease Unit, 75010 Paris, France.
I ColmegnaMcGill University, Department of Medicine, Montreal, Québec, Canada.
D Bonnefont-RousselotAssistance Publique Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Department of Metabolic Biochemistry, 75013 Paris, France; Paris University, UTCBS, INSERM U1267, CNRS UMR 8258, 75006 Paris, France.
D FargeAssistance Publique Hôpitaux de Paris, Saint-Louis Hospital, Department of Internal Medicine, Autoimmune and Vascular Disease Unit, 75010 Paris, France; McGill University, Department of Medicine, Montreal, Québec, Canada; Paris University, EA 3518, University Institute of Hematology, 75010 Paris, France.
C FrereAssistance Publique Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Department of Hematology, 75013 Paris, France; Sorbonne University, INSERM UMRS_1166, Institute of Cardiometabolism And Nutrition, 75013 Paris, France. Electronic address: corinne.frere@aphp.fr.
Assistance Publique – Hôpitaux de Paris · FRSorbonne Université · FRDana-Farber Brigham Cancer Center · USMcGill University · CAPitié-Salpêtrière Hospital · FRUniversité Paris Cité · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeveral observational studies have reported elevated baseline D-dimer levels in patients hospitalized for moderate to severe coronavirus disease 2019 (COVID-19). These elevated baseline D-dimer levels have been associated with disease severity and mortality in retrospective cohorts.

objectivesTo review current available data on the association between D-Dimer levels and mortality in patients admitted to hospital for COVID-19.

methodsWe performed a systematic review of published studies using MEDLINE and EMBASE through 13 April 2020. Two authors independently screened all records and extracted the outcomes. A random effects model was used to estimate the standardized mean difference (SMD) with 95% confidence intervals (CI).

resultsSix original studies enrolling 1355 hospitalized patients with moderate to critical COVID-19 (391 in the non-survivor group and 964 in the survivor group) were considered for the final pooled analysis. When pooling together the results of these studies, D-Dimer levels were found to be higher in non-survivors than in-survivors. The SMD in D-Dimer levels between non-survivors and survivors was 3.59μg/L (95% CI 2.79-4.40μg/L), and the Z-score for overall effect was 8.74 (P<0.00001), with a high heterogeneity across studies (I

conclusionsDespite high heterogeneity across included studies, the present pooled analysis indicates that D-Dimer levels are significantly associated with the risk of mortality in COVID-19 patients. Early integration of D-Dimer testing, which is a rapid, inexpensive, and easily accessible biological test, can be useful to better risk stratification and management of COVID-19 patients.

Indexed as

BetacoronavirusBiomarkersCoronavirus InfectionsCOVID-19FemaleFibrin Fibrinogen Degradation ProductsHospitalizationHumansMaleMiddle AgedPandemicsPneumonia, ViralRetrospective StudiesRisk AssessmentSARS-CoV-2Severity of Illness IndexBiomarkersFibrin Fibrinogen Degradation Productsfibrin fragment DbiomarkerCoronavirus disease 2019D-DimerMortalitySARS-CoV-2

Identifiers

PMID32862984
PMCPMC7250752
OpenAlexW3030113472

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.