ArticleBrain and behavior2020
FMRI activation to cannabis odor cues is altered in individuals at risk for a cannabis use disorder.
Article in Brain and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Patterns of brain function associated with cannabis cue-reactivity in regular cannabis users: a systematic review of fMRI studies.Psychopharmacology · 2021Pooled it
- The Neurocircuitry of Cannabis Cue Reactivity in Cannabis Use Disorder: A Functional Neuroimaging Study.Biological psychiatry global open science · 2026Article
- Increased Mesostriatal Intrinsic Connectivity Associated With Cue Exposure in Adult Cannabis Users: Preliminary Findings.Addiction biology · 2025Article
- NeuroTree: Hierarchical Functional Brain Pathway Decoding for Mental Health Disorders.Proceedings of machine learning research · 2025Article
- Validity Concerns About the Heartbeat Counting Task Extend to Alcohol Use disorder: Evidence From Subclinical and Clinical Samples.Addiction biology · 2025Article
- Exploring the Utility of a Functional Magnetic Resonance Imaging Cannabis Cue-Reactivity Paradigm in Treatment-Seeking Adults With Cannabis Use Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- fNIRS a novel neuroimaging tool to investigate olfaction, olfactory imagery, and crossmodal interactions: a systematic review.Frontiers in neuroscience · 2024Review
- Sex Differences in Substance Use Disorders: A Neurobiological Perspective.Frontiers in global women's health · 2021Review
- FMRI activation to cannabis odor cues is altered in individuals at risk for a cannabis use disorder.Brain and behavior · 2020Article
- Functional Domains of Substance Use and their Implications to Trauma: A Systematic Review of Neuroimaging Studies.Chronic stress (Thousand Oaks, Calif.)Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
introductionThe smell of cannabis is a cue with universal relevance to cannabis users. However, most cue reactivity imaging studies have solely utilized visual images, auditory imagery scripts, or tactile cues in their experiments. This study introduces a multimodal cue reactivity paradigm that includes picture, odor, and bimodal picture + odor cues.
methodsTwenty-eight adults at risk for cannabis use disorder (CUD; defined as at least weekly use and Substance Involvement Score of ≥4 on the Cannabis sub-test of the Alcohol, Smoking and Substance Involvement Screening Test) and 26 cannabis-naive controls were exposed to cannabis and floral cues during event-related fMRI. Between-group differences in fMRI activation and correlations were tested using FMRIB's Local Analyses of Mixed Effects and corrected for multiple comparisons using a voxelwise threshold of z > 2.3 and a corrected cluster threshold of p < .05.
resultsBoth visual and olfactory modalities resulted in significant activation of craving and reward systems, with cannabis odor cues eliciting a significantly greater response in regions mediating anticipation and reward (nucleus accumbens, pallidum, putamen, and anterior insular cortex, supplementary motor area, angular gyrus and superior frontal gyrus) and cannabis picture cues eliciting a significantly greater response in the occipital cortex and amygdala. Furthermore, the CUD group showed significantly increased activation in the ventral tegmental area (VTA), the insula, and the pallidum compared to controls. Within the CUD group, activation in the insula, anterior cingulate, and occipital cortex to bimodal cannabis cues was significantly correlated with self-reported craving.
conclusionOur multimodal cue reactivity paradigm is sensitive to neural adaptations associated with problematic cannabis use.
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