Evidence map›Paper›PMID 32862489›Full record

ArticleJournal of clinical laboratory analysis2020

miR-212 as potential biomarker suppresses the proliferation of gastric cancer via targeting SOX4.

Jian-Ping Shao, Feng Su, Shu-Peng Zhang, He-Kai Chen, Zhao-Jin Li, Guo-Qiang Xing, Hong-Jie Liu, Yong-Yuan Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical laboratory analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jian-Ping ShaoDepartment of General Surgery, The Fifth Central Hospital of Tianjin, Tianjin, China.
Feng SuDepartment of General Surgery, The Fifth Central Hospital of Tianjin, Tianjin, China.
Shu-Peng ZhangDepartment of General Surgery, The Fifth Central Hospital of Tianjin, Tianjin, China.
He-Kai ChenDepartment of General Surgery, The Fifth Central Hospital of Tianjin, Tianjin, China.
Zhao-Jin LiDepartment of General Surgery, The Fifth Central Hospital of Tianjin, Tianjin, China.
Guo-Qiang XingDepartment of General Surgery, The Fifth Central Hospital of Tianjin, Tianjin, China.
Hong-Jie LiuDepartment of Radiology, The Fifth Central Hospital of Tianjin, Tianjin, China.
Yong-Yuan LiDepartment of General Surgery, The Fifth Central Hospital of Tianjin, Tianjin, China.ORCID https://orcid.org/0000-0003-2855-7380
Fifth Tianjin Central Hospital · CN

Funding

Medical Research Project of the Fifth Central Hospital of Tianjin wzx202001The Science and Technology Project of Health and Family Planning Commission of Tianjin Binhai New District 2018BWKZ004
6 · The paper itself

Abstract

backgroundCirculating microRNAs that post-transcriptionally regulate gene expressions have been reported as promising biomarkers in cancer monitoring. This study was to identify the potential role of circulating miR-212 in gastric cancer and whether it could serve as a novel biomarker for gastric cancer.

methodsWe detected the serum levels of miR-212 in 100 health people and 110 gastric cancer patients and analyzed the relationships of the serum level of miR-212 with gastric cancer. We detected the expression of miR-212 in human gastric mucosal epithelial cell line (GES-1) and human gastric cancer cell lines (NCI-N87 and SNU-16) using qRT-PCR. Then, we detected the role of 5-aza-deoxycytidine on the epigenetic regulation of miR-212 in human gastric cancer cell lines. Furthermore, luciferase reporter assay was used to detect binding activity of miR-212 on SOX4 mRNA, and their functions on the cell proliferation and apoptosis.

resultsThe expression of miR-212 was higher in health people than that in gastric cancer patients, higher in gastric mucosal epithelial cell line than that in gastric cancer cells. miR-212 can be a circulating biomarker and an independent prognostic factor of gastric cancer. Moreover, miR-212 can directly regulate the 3'UTR of SOX4 mRNA to suppress p53 and Bax, resulting gastric cancer cells proliferation inhibition and apoptosis induction.

conclusionOur study demonstrated that miR-212 was epigenetically downregulated in gastric cancer, and resulting low level of miR-212 can be a potential circulating biomarker and poor prognosis predicator of gastric cancer.

Indexed as

Stomach NeoplasmsAdultAgedAged, 80 and overAntimetabolites, AntineoplasticBiomarkers, TumorCell Line, TumorDecitabineFemaleHumansMaleMicroRNAsMiddle AgedPrognosisSOXC Transcription FactorsAntimetabolites, AntineoplasticBiomarkers, TumorDecitabineMicroRNAsMIRN212 microRNA, humanSOX4 protein, humanSOXC Transcription Factors5-aza-deoxycytidinecirculation microRNAgastric cancermiR-212SOX4

Identifiers

PMID32862489
PMCPMC7755761
OpenAlexW3081998116

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.