Evidence map›Paper›PMID 32862401›Full record

ReviewTranslational stroke research2021

Neurogenesis After Stroke: A Therapeutic Perspective.

Abir A Rahman, Narayanappa Amruta, Emmanuel Pinteaux, Gregory J Bix

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Translational stroke research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Abir A RahmanClinical Neuroscience Research Center, Department of Neurosurgery, Tulane University School of Medicine, Room 1349, 131 S. Robertson, Ste 1300, New Orleans, LA, 70112, USA.ORCID https://orcid.org/0000-0002-0940-1527
Narayanappa AmrutaClinical Neuroscience Research Center, Department of Neurosurgery, Tulane University School of Medicine, Room 1349, 131 S. Robertson, Ste 1300, New Orleans, LA, 70112, USA.ORCID http://orcid.org/0000-0003-1388-9702
Emmanuel PinteauxFaculty of Biology, Medicine and Health, University of Manchester, A.V. Hill Building, Oxford Road, Manchester, M13 9PT, UK.ORCID https://orcid.org/0000-0002-9986-4401
Gregory J BixClinical Neuroscience Research Center, Department of Neurosurgery, Tulane University School of Medicine, Room 1349, 131 S. Robertson, Ste 1300, New Orleans, LA, 70112, USA. gbix@tulane.edu.ORCID https://orcid.org/0000-0002-8969-9553

Funding

The Role of Perlecan Domain V in Vascular DementiaR01NS089515 · NINDS · UNIVERSITY OF KENTUCKY · PI BIX, GREGORY JAYE · 2014 to 2018
$1.6M
Interleukin-1 alpha as a novel treatment for ischemic strokeR01NS101752 · NINDS · UNIVERSITY OF KENTUCKY · PI BIX, GREGORY JAYE, PINTEAUX, EMMANUEL · 2018 to 2022
$1.5M
NINDS NIH HHS R01 NS089515NINDS NIH HHS R01NS089515NINDS NIH HHS R01 NS101752NINDS NIH HHS R01NS101752
6 · The paper itself

Abstract

Stroke is a major cause of death and disability worldwide. Yet therapeutic strategies available to treat stroke are very limited. There is an urgent need to develop novel therapeutics that can effectively facilitate functional recovery. The injury that results from stroke is known to induce neurogenesis in penumbra of the infarct region. There is considerable interest in harnessing this response for therapeutic purposes. This review summarizes what is currently known about stroke-induced neurogenesis and the factors that have been identified to regulate it. Additionally, some key studies in this field have been highlighted and their implications on future of stroke therapy have been discussed. There is a complex interplay between neuroinflammation and neurogenesis that dictates stroke outcome and possibly recovery. This highlights the need for a better understanding of the neuroinflammatory process and how it affects neurogenesis, as well as the need to identify new mechanisms and potential modulators. Neuroinflammatory processes and their impact on post-stroke repair have therefore also been discussed.

Indexed as

AnimalsBrainBrain IschemiaHumansNeurogenesisNeuroprotective AgentsRecovery of FunctionStem Cell TransplantationStrokeNeuroprotective AgentsCytokinesNeurogenesisNeuroinflammationStrokeStroke therapy

Identifiers

PMID32862401
PMCPMC7803692

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.