Evidence map›Paper›PMID 32862381›Full record

ArticleCurrent medical science2020

Neuroprotective Effects of Dexmedetomidine Preconditioning on Oxygen-glucose Deprivation-reoxygenation Injury in PC12 Cells via Regulation of Ca

Yi-da Hu, Chao-Liang Tang, Jia-Zhen Jiang, Hai-Yan Lv, Yuan-Bo Wu, Xiu-de Qin, Si Shi, Bo Zhao, Xiao-Nan Zhu, Zhong-Yuan Xia

Abstract read
PubMed Publisher
In one paragraph

Article in Current medical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Target Molecules of STIM Proteins in the Central Nervous System.Frontiers in molecular neuroscience · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Yi-da HuDepartment of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Chao-Liang TangDepartment of Anesthesiology, the First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China.
Jia-Zhen JiangDepartment of Emergency, Huashan Hospital North, Fudan University, Shanghai, 201907, China.
Hai-Yan LvDepartment of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, 201620, China.
Yuan-Bo WuDepartment of Neurology, the First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China.
Xiu-de QinDepartment of Neurology, Shenzhen Traditional Chinese Medicine Hospital, the Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, 518033, China.
Si ShiDepartment of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Bo ZhaoDepartment of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Xiao-Nan ZhuDepartment of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Zhong-Yuan XiaDepartment of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China. xiazhongyuan2005@aliyun.com.
Wuhan University · CNUniversity of Science and Technology of China · CNFudan University · CNGuangzhou University of Chinese Medicine · CNShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dexmedetomidine (DEX), a potent and highly selective agonist for α

Indexed as

AnimalsApoptosisAutophagyCalcium SignalingDexmedetomidineGene Expression RegulationModels, BiologicalNeuroprotective AgentsORAI1 ProteinOxidative StressPC12 CellsRatsReperfusion InjuryStromal Interaction Molecule 1DexmedetomidineNeuroprotective AgentsORAI1 ProteinOrai1 protein, ratStim1 protein, ratStromal Interaction Molecule 1autophagyCa2+dexmedetomidineneuronal apoptosisneuroprotectionPC12 cellsSTIM1/Orai1

Identifiers

PMID32862381
OpenAlexW3082300654

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.