Evidence map›Paper›PMID 32862331›Full record

ArticleNeuromolecular medicine2020

Transcriptomic Heterogeneity of Alzheimer's Disease Associated with Lipid Genetic Risk.

Xiao Miao, Weifeng Liu, Bin Fan, Honghuang Lin

Abstract read
PubMed Publisher
In one paragraph

Article in Neuromolecular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Xiao MiaoYueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Weifeng LiuYueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Bin FanYueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Honghuang LinSection of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, 72 East Concord Street, E-632, Boston, MA, 02118, USA. hhlin@bu.edu.ORCID 0000-0003-3043-3942
Shanghai University of Traditional Chinese Medicine · CNBoston University · US

Funding

NATIONAL ALZHEIMERS COORDINATING CENTER (NACC)U01AG016976 · NIA · UNIVERSITY OF WASHINGTON · PI KUKULL, WALTER ANTHONY · 1999 to 2020
$72.8M
THE NIA GENETICS OF ALZHEIMER'S DISEASE DATA STORAGE SITEU24AG041689 · NIA · UNIVERSITY OF PENNSYLVANIA · PI LI-SAN WANG · 2012 to 2026
$42.3M
NIA NIH HHS U01 AG016976NIA NIH HHS U24 AG041689
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a multifactorial disease that affects more than 5 million Americans. Multiple pathways might be involved in the AD pathogenesis. The implication of lipid genetic susceptibility on brain gene expression is yet to be investigated. The current study included 192 brain samples from AD patients who were enrolled in the ROSMAP study. The samples were genotyped and imputed to the HRC Reference Panel. Lipid polygenetic risk score was constructed from the weighted sum of genetic variants associated with low-density lipoprotein cholesterol (LDL-C). The gene expression was profiled by RNA sequencing, and the  association of gene expression with lipid polygenetic risk scores was tested by linear regression models adjusted for age, sex and APOE e4 alleles. Three genes were found to associate with lipid polygenetic risk scores, including HMCN2 (P = 3.6 × 10

Indexed as

TranscriptomeAdaptor Proteins, Signal TransducingAgedAged, 80 and overAlzheimer DiseaseApolipoprotein E4Cholesterol, LDLEducational StatusFemaleGene Regulatory NetworksGenetic Association StudiesGenetic Predisposition to DiseaseHumansLIM Domain ProteinsMaleMolecular Sequence AnnotationAdaptor Proteins, Signal TransducingApolipoprotein E4Cholesterol, LDLFHL5 protein, humanLIM Domain ProteinsPDLIM5 protein, humanTranscription FactorsAlzheimer’s diseaseGene expressionInteraction networkLipid metabolism

Identifiers

PMID32862331
OpenAlexW3081814543

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.