Evidence map›Paper›PMID 32862321›Full record

ArticleEndocrine2021

High pre-operative fasting blood glucose levels predict a poor prognosis in patients with pancreatic neuroendocrine tumour.

Yitao Gong, Zhiyao Fan, Pin Zhang, Yunzhen Qian, Qiuyi Huang, Shengming Deng, Guopei Luo, He Cheng, Kaizhou Jin, Quanxing Ni and 2 more

Abstract read
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In one paragraph

Article in Endocrine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yitao Gong *Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, 200032, Shanghai, China.
Zhiyao Fan *Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, 200032, Shanghai, China.
Pin Zhang *Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, 200032, Shanghai, China.
Yunzhen QianDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, 200032, Shanghai, China.
Qiuyi HuangDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, 200032, Shanghai, China.
Shengming DengDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, 200032, Shanghai, China.
Guopei LuoDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, 200032, Shanghai, China.
He ChengDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, 200032, Shanghai, China.
Kaizhou JinDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, 200032, Shanghai, China.
Quanxing NiDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, 200032, Shanghai, China.
Xianjun YuDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, 200032, Shanghai, China. yuxianjun@fudanpci.org.
Chen LiuDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, 200032, Shanghai, China. liuchen@fudanpci.org.

Funding

National Natural Science Foundation of China (CN) 81625016, 81871940, 81902417
6 · The paper itself

Abstract

backgroundHyperglycaemia has been indicated as a pro-tumoural factor; however, the prognostic role of diabetes mellitus (DM) in pancreatic neuroendocrine tumours (panNETs) remains ambiguous, partly due to the effects of anti-diabetic drugs. We hypothesise that the blood sugar level per se affects the outcome of panNETs, and thus, we investigated the prognostic significance of the fasting blood glucose (FBG) level in resected panNET patients with no pre-existing DM.

methodsA retrospective cohort study comprising 201 patients with radically resected non-functional panNETs was conducted. A total of 164 patients without pre-existing DM were further studied. An FBG level greater than 5.6 mmol/L was defined as high (otherwise, normal). Survival was evaluated using Kaplan-Meier methods and log-rank tests. Multivariate analyses for survival were performed using the Cox regression model.

resultsHigh FBG levels were significantly associated with poor overall survival (OS; p = 0.019) and recurrence-free survival (RFS; p = 0.011) in resected patients with panNET who had no pre-existing DM. The multivariable-adjusted hazard ratios (HRs) for mortality and recurrence comparing patients with high and normal FBG levels were 12.19 (95% confidence interval (CI) = 1.15-128.78, p = 0.038) and 2.43 (95% CI = 1.03-5.72, p = 0.042), respectively.

conclusionA pre-operative FBG level greater than 5.6 mmol/L is associated with poor OS and RFS metastasis for patients with panNET who undergo radical surgical resection.

Indexed as

HyperglycemiaPancreatic NeoplasmsBlood GlucoseFastingHumansPrognosisRetrospective StudiesBlood GlucoseDiabetes mellitusHyperglycaemiaImpaired glucose tolerancePrediabetes

Identifiers

PMID32862321

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.